Compile Data Set for Download or QSAR
Report error Found 76 Enz. Inhib. hit(s) with all data for entry = 50032250
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326208(4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326207(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataEC50:  15nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataEC50:  15nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326204(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 17nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326211(5-Fluoro-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataEC50:  20nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326207(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 22nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326208(4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...)
Affinity DataEC50:  24nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326210(2-(4-Fluorophenylamino)-N-(4-(3-(2-(methylamino)py...)
Affinity DataEC50:  28nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326202(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 56nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 66nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326204(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataEC50:  89nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326205(N-(2-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 110nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326203(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 251nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326201(4-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidi...)
Affinity DataIC50: 335nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 385nMAssay Description:Inhibition of LCK by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326200(3-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidi...)
Affinity DataIC50: 430nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 503nMAssay Description:Inhibition of Abl by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326209(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 542nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 630nMAssay Description:Inhibition of Tie-2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EphB4 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IGFR1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Zap70 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Jak2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PLK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Erk1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PKBalpha by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK5 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Jak3 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BTK by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of JNK2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of p70s6k by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326202(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataEC50: >1.20E+3nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326201(4-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidi...)
Affinity DataEC50: >1.20E+3nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326200(3-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidi...)
Affinity DataEC50: >1.20E+3nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataEC50: >1.20E+3nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326203(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataEC50: >1.20E+3nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandPNGBDBM50326198(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of c-Kit by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326205(N-(2-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataEC50:  1.45E+3nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandPNGBDBM50326198(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of c-Fms by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandPNGBDBM50326198(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 3.27E+3nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandPNGBDBM50326198(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 5.75E+3nMAssay Description:Inhibition of Src by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandPNGBDBM50326198(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of PKBalpha by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CDK5 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of EphB4 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
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