Compile Data Set for Download or QSAR
maximum 50k data
Found 76 Enz. Inhib. hit(s) with all data for entry = 50032250
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326208(4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326204(CHEMBL1243137 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  17nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326207(CHEMBL1243294 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326202(CHEMBL1243042 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  56nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  66nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326205(CHEMBL1243167 | N-(2-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  110nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326203(CHEMBL1243073 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  251nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326201(4-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidi...)
Affinity DataIC50:  335nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  385nMAssay Description:Inhibition of LCK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326200(3-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidi...)
Affinity DataIC50:  430nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  503nMAssay Description:Inhibition of Abl by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326209(CHEMBL1243108 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  542nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  630nMAssay Description:Inhibition of Tie-2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CDK1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PKBalpha by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CDK5 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Erk1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PLK1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of p70s6k by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of JNK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of BTK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Jak3 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Jak2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Zap70 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of IGFR1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of EphB4 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CDK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  1.35E+3nMAssay Description:Inhibition of c-Kit by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  1.58E+3nMAssay Description:Inhibition of c-Fms by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  3.27E+3nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  5.75E+3nMAssay Description:Inhibition of Src by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of JNK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of BTK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of Jak3 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of Jak2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of Zap70 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of IGFR1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of EphB4 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of P38alpha by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of p70s6k by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of PLK1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of CDK5 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of Erk1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of PKBalpha by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326199(2-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidi...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326208(4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of p70s6k by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 76 total ) | Next | Last >>
Jump to: