Compile Data Set for Download or QSAR
Report error Found 314 Enz. Inhib. hit(s) with all data for entry = 50038381
TargetEpidermal growth factor receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3556(PD153035 Analog | 4-[(3-Bromophenyl)amino]-6,7-die...)
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of wild type EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL29197 | N-(3-bromophenyl)-6,7-dimethoxyquina...)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL29197 | N-(3-bromophenyl)-6,7-dimethoxyquina...)
Affinity DataIC50: 0.0250nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3303(4-N-(3-bromophenyl)quinazoline-4,6,7-triamine | CH...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of wild type EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM84533(BDBM50375663 | Alsterpaullone derivative, 7)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM84533(BDBM50375663 | Alsterpaullone derivative, 7)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375642(KRN-633 | CHEMBL406381)
Affinity DataIC50: 1nMAssay Description:Inhibition of human VEGFR1 in HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Tyk2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375656(ARCTIGENIN)
Affinity DataIC50: 1nMAssay Description:Inhibition of MKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375642(KRN-633 | CHEMBL406381)
Affinity DataIC50: 1nMAssay Description:Inhibition of human VEGFR2 in HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM2580(methyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of CaM-KKbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM25018(thienopyrimidine derivative, 1 | CHEMBL541643 | 3-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of p110-alpha PI kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM4622(CHEMBL127907 | 3-[(6,7-dimethoxyquinazolin-4-yl)am...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PI3KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM15908(N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-di...)
Affinity DataKi:  2nMAssay Description:Inhibition of human JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PKCgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PKCbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM4815(5-{[(3Z)-5-chloro-2-oxo-2,3-dihydro-1H-indol-3-yli...)
Affinity DataIC50: 3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375639(CHEMBL258940)
Affinity DataIC50: 3nMAssay Description:Inhibition of Her1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375639(CHEMBL258940)
Affinity DataIC50: 3nMAssay Description:Inhibition of Her1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375639(CHEMBL258940)
Affinity DataIC50: 3nMAssay Description:Inhibition of ErbB1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50142887(1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...)
Affinity DataIC50: 4nMAssay Description:Inhibition of p56lck autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM15908(N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-di...)
Affinity DataKi:  4nMAssay Description:Inhibition of human JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50005298(CHEMBL337300)
Affinity DataIC50: 5nMAssay Description:Inhibition of Cdk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375644(CHEMBL440411)
Affinity DataIC50: 5nMAssay Description:Inhibition of Cdk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM7401(6-bromoindirubin-3 -oxime | (3E)-6-bromo-3-[3-(hyd...)
Affinity DataIC50: 5nMAssay Description:Binding affinity to GSK3alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50153461(3-(1-(3-imidazol-1-ylpropyl)-1H-indol-3-yl)-4-anil...)
Affinity DataIC50: 5nMAssay Description:Inhibition of PKCbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 5nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50142887(1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...)
Affinity DataIC50: 5nMAssay Description:Inhibition of HckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM7491(4-[2-Amino-5-oxo-1,5-dihydro-imidazol-(4Z)-ylidene...)
Affinity DataIC50: 6nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375644(CHEMBL440411)
Affinity DataIC50: 7nMAssay Description:Inhibition of Cdk5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50005298(CHEMBL337300)
Affinity DataIC50: 9nMAssay Description:Binding affinity to GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50: 9nMAssay Description:Inhibition of Cdk9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50005298(CHEMBL337300)
Affinity DataIC50: 9nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375653(CHEMBL264949)
Affinity DataIC50: 9nMAssay Description:Inhibition of cRAF1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM4815(5-{[(3Z)-5-chloro-2-oxo-2,3-dihydro-1H-indol-3-yli...)
Affinity DataIC50: 10nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50325991(CHEMBL1242100 | CHEMBL541400 | CHEMBL1190711 | 2-(...)
Affinity DataIC50: 10nMAssay Description:Inhibition of SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375655(CHEMBL259605)
Affinity DataIC50: 11nMAssay Description:Inhibition of Aurora kinase AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375661(CHEMBL404609)
Affinity DataIC50: 13nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375638(CHEMBL101797)
Affinity DataIC50: 14nMAssay Description:Inhibition of SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK4(Mouse)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM80396(cid_1893667 | (1E)-1-(3-ethyl-5-methoxy-1,3-benzot...)
Affinity DataIC50: 15nMAssay Description:Inhibition of mouse Clk4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Mouse)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 15nMAssay Description:Inhibition of mouse JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM34064(CHEMBL179583 | 2-arylbenzimidazole)
Affinity DataIC50: 15nMAssay Description:Inhibition of Chk2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM34064(CHEMBL179583 | 2-arylbenzimidazole)
Affinity DataIC50: 15nMAssay Description:Inhibition of Chk2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM6763(28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Chk1 mediated phosphorylation of cdc25CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM25018(thienopyrimidine derivative, 1 | CHEMBL541643 | 3-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of p110-beta PI kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
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