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maximum 50k data
Found 43 Enz. Inhib. hit(s) with all data for entry = 9842
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataKi:  0.390nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248946(CHEMBL1908392 | US10981896, Compound 16)
Affinity DataKi:  0.470nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248938(CHEMBL4089284 | US10981896, Compound 21)
Affinity DataKi:  0.680nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248946(CHEMBL1908392 | US10981896, Compound 16)
Affinity DataKi:  1.70nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248946(CHEMBL1908392 | US10981896, Compound 16)
Affinity DataKi:  4.20nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248938(CHEMBL4089284 | US10981896, Compound 21)
Affinity DataKi:  4.90nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataKi:  7nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248938(CHEMBL4089284 | US10981896, Compound 21)
Affinity DataKi:  8.60nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataKi:  9.20nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248946(CHEMBL1908392 | US10981896, Compound 16)
Affinity DataKi:  10nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataKi:  11nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248946(CHEMBL1908392 | US10981896, Compound 16)
Affinity DataKi:  15nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataKi:  31nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248938(CHEMBL4089284 | US10981896, Compound 21)
Affinity DataKi:  81nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataKi:  84nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248938(CHEMBL4089284 | US10981896, Compound 21)
Affinity DataKi:  85nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM492925(US10981896, Compound 14)
Affinity DataKi: >650nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM492924(US10981896, Compound 8)
Affinity DataKi: >650nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM492923(US10981896, Compound 6)
Affinity DataKi: >650nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248946(CHEMBL1908392 | US10981896, Compound 16)
Affinity DataKi:  1.16E+3nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataKi:  3.00E+3nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248938(CHEMBL4089284 | US10981896, Compound 21)
Affinity DataKi:  1.90E+4nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataIC50:  3nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248946(CHEMBL1908392 | US10981896, Compound 16)
Affinity DataIC50:  3.60nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248938(CHEMBL4089284 | US10981896, Compound 21)
Affinity DataIC50:  5.20nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248936(CHEMBL4083922 | US10981896, Compound 25)
Affinity DataIC50:  18nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248945(CHEMBL4081410 | US10981896, Compound 19)
Affinity DataIC50:  24nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataIC50:  43nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataIC50:  43nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248936(CHEMBL4083922 | US10981896, Compound 25)
Affinity DataIC50:  67nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM192753(Hesperadin | US10981896, Compound Hesperadin)
Affinity DataIC50:  225nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50109821(CHEBI:87103 | CHEMBL21156 | US10981896, Compound 4...)
Affinity DataIC50:  330nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM492908(US10981896, Compound CC401)
Affinity DataIC50:  340nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248947(CHEMBL4075402 | US10981896, Compound 18)
Affinity DataIC50:  354nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)
Affinity DataIC50:  400nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM492910(US10981896, Compound HA-1004)
Affinity DataIC50:  440nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50243388(AT-9283 | US10981896, Compound AT9283)
Affinity DataIC50:  685nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248944(CHEMBL4088537 | US10981896, Compound 527450)
Affinity DataIC50:  720nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM4815(5-{[(3Z)-5-chloro-2-oxo-2,3-dihydro-1H-indol-3-yli...)
Affinity DataIC50:  760nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM492914(US10981896, Compound AZD776)
Affinity DataIC50:  900nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248924(CHEMBL4099431 | US10981896, Compound 20)
Affinity DataIC50:  1.15E+3nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248925(CHEMBL4061117 | US10981896, Compound 22)
Affinity DataIC50:  2.70E+3nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50248935(CHEMBL4062202 | US10981896, Compound 23)
Affinity DataIC50: >5.00E+3nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent