Reaction Details
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Target
Cathepsin B-like cysteine protease
Ligand
BDBM22046
Substrate
BDBM22047
Meas. Tech.
Enzyme Inhibition Assay
pH
5.5±n/a
Temperature
295.15±n/a K
IC50
14000±3000 nM
Citation
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Target
Name:
Cathepsin B-like cysteine protease
Synonyms:
CPC | Cathepsin B-Like Cysteine Protease (TbcatB) | Cysteine peptidase C | TbcatB
Type:
Enzyme
Mol. Mass.:
37220.37
Organism:
Trypanosoma brucei
Description:
Enzyme was expressed in yeast Pichia pastoris.
Residue:
340
Sequence:
MHLMRACITFCIASTAVVAVNAALVAEDAPVLSKAFVDRVNRLNRGIWKAKYDGVMQNITLREAKRLNGVIKKNNNASILPKRRFTEEEARAPLPSSFDSAEAWPNCPTIPQIADQSACGSCWAVAAASAMSDRFCTMGGVQDVHISAGDLLACCSDCGDGCNGGDPDRAWAYFSSTGLVSDYCQPYPFPHCSHHSKSKNGYPPCSQFNFDTPKCNYTCDDPTIPVVNYRSWTSYALQGEDDYMRELFFRGPFEVAFDVYEDFIAYNSGVYHHVSGQYLGGHAVRLVGWGTSNGVPYWKIANSWNTEWGMDGYFLIRRGSSECGIEDGGSAGIPLAPNTA
Inhibitor
Name:
BDBM22046
Synonyms:
9-cyclopentyl-6-{[(2S)-2-methylbutyl]amino}-9H-purine-2-carbonitrile | Compound 3{1,13}
Type:
Small organic molecule
Emp. Form.:
C16H22N6
Mol. Mass.:
298.3861
SMILES:
CC[C@H](C)CNc1nc(nc2n(cnc12)C1CCCC1)C#N |r|
Substrate
Name:
BDBM22047
Synonyms:
CBZ-Phe-Arg 7-amido-4-methylcoumarin | Z-Phe-Arg-AMC
Type:
Fluorogenic substrate
Emp. Form.:
C33H36N6O6
Mol. Mass.:
612.6755
SMILES:
[#6]-c1cc(=O)oc2cc(-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c3ccccc3)-[#7]-[#6](=O)-[#8]-[#6]-c3ccccc3)ccc12