Report error Found 1049 with Last Name = 'connelly' and Initial = 'm'
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of rat PDE10A by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetCholesteryl ester transfer protein(Human)
Johnson and Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson and Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of CETP (unknown origin)-mediated transfer of [3H]cholesteryl ester from HDL donar particles to LDL acceptor particles in presence of buff...More data for this Ligand-Target Pair
TargetCholesteryl ester transfer protein(Human)
Johnson and Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson and Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of CETP (unknown origin)-mediated transfer of [3H]cholesteryl ester from HDL donar particles to LDL acceptor particlesMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: <5nMAssay Description:All rate-based assays were performed in black 384-well polypropylene polymerase chain reaction (PCR) microplates (Abgene) in a total volume of 30 ...More data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant His-tagged NAE1 expressed in baculovirus expression system after 90 mins in presence of FLAG-tagged NEDD8 by TR-FRET ...More data for this Ligand-Target Pair
Affinity DataIC50: <5nMAssay Description:All rate-based assays were performed in black 384-well polypropylene polymerase chain reaction (PCR) microplates (Abgene) in a total volume of 30 ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Affinity DataIC50: 10.1nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of human ATM using p53 as substrate preincubated for 10 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Binding affinity for Adenosine A1 receptor using N-[3H] cyclohexyladenosine in rat forebrain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of flag-tagged ATM (unknown origin) using p53 as substrate by ELISAMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Time dependent inhibition of human EL (19 to 500) expressed in HEK293 cells using PED-A1 as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human BRD2 bromodomain 2 (342 to 460 residues) using biotin labeled peptide substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair