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Target
Cathepsin S
Ligand
BDBM19769
Substrate
n/a
Meas. Tech.
ChEMBL_216712 (CHEMBL818677)
Ki
4±n/a nM
Citation
Marquis, RW; Ru, Y; LoCastro, SM; Zeng, J; Yamashita, DS; Oh, HJ; Erhard, KF; Davis, LD; Tomaszek, TA; Tew, D; Salyers, K; Proksch, J; Ward, K; Smith, B; Levy, M; Cummings, MD; Haltiwanger, RC; Trescher, G; Wang, B; Hemling, ME; Quinn, CJ; Cheng, HY; Lin, F; Smith, WW; Janson, CA; Zhao, B; McQueney, MS; D'Alessio, K; Lee, CP; Marzulli, A; Dodds, RA; Blake, S; Hwang, SM; James, IE; Gress, CJ; Bradley, BR; Lark, MW; Gowen, M; Veber, DF Azepanone-based inhibitors of human and rat cathepsin K. J Med Chem 44:1380-95 (2001) [PubMed] Article
More Info.:
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
Inhibitor
Name:
BDBM19769
Synonyms:
(2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4S)-3-oxo-1-(pyridine-2-sulfonyl)azepan-4-yl]pentanamide | Azepan-3-one compound 1 | CHEMBL286364
Type:
Small organic molecule
Emp. Form.:
C26H30N4O6S
Mol. Mass.:
526.605
SMILES:
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CCCN(CC1=O)S(=O)(=O)c1ccccn1 |r|