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Target
Histone deacetylase 2b
Ligand
BDBM50166153
Substrate
n/a
Meas. Tech.
ChEMBL_305568 (CHEMBL827162)
IC50
570±n/a nM
Citation
 Mai, A; Massa, S; Pezzi, R; Simeoni, S; Rotili, D; Nebbioso, A; Scognamiglio, A; Altucci, L; Loidl, P; Brosch, G Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides. J Med Chem 48:3344-53 (2005) [PubMed]  Article 
Target
Name:
Histone deacetylase 2b
Synonyms:
Histone deacetylase HD2
Type:
PROTEIN
Mol. Mass.:
30785.07
Organism:
Zea mays
Description:
ChEMBL_87549
Residue:
286
Sequence:
MEVGGQEVKPGATVSCKVGDGLVIHLSQAALGESKKASENAILSVNIDDKKLVLGTLSVEKHPQISCDLVFDKDFELPHNSKTRSVFFRGYKSPVPLFESNSGEDSSDEELKTDQIPLQNNEIKISAAKVPAKDDDDDVFIILAMMMMIYSSDDDDDDFTTSDSDNEMSEEDDSSDEDEMSEEDDSSDEDEMSGGADPSDDSSDESGSEHTSAPKKTDVVVGKKRAIKAEAPYGKKAKSEQSSQKTGDKASTSHPAKQSIKTPADKSRKTPTADKKSPKSGSHGCK
  
Inhibitor
Name:
BDBM50166153
Synonyms:
(E)-N-Hydroxy-3-{4-[3-(4-methoxy-phenyl)-3-oxo-propenyl]-1-methyl-1H-pyrrol-2-yl}-acrylamide | CHEMBL191623 | N-hydroxy-3-(4-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)acrylamide
Type:
Small organic molecule
Emp. Form.:
C18H18N2O4
Mol. Mass.:
326.3465
SMILES:
COc1ccc(cc1)C(=O)\C=C\c1cc(\C=C\C(=O)NO)n(C)c1
Structure:
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