Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 2
Ligand
BDBM50395285
Substrate
n/a
Meas. Tech.
ChEMBL_860389 (CHEMBL2166172)
IC50
4±n/a nM
Citation
Kosugi, T; Mitchell, DR; Fujino, A; Imai, M; Kambe, M; Kobayashi, S; Makino, H; Matsueda, Y; Oue, Y; Komatsu, K; Imaizumi, K; Sakai, Y; Sugiura, S; Takenouchi, O; Unoki, G; Yamakoshi, Y; Cunliffe, V; Frearson, J; Gordon, R; Harris, CJ; Kalloo-Hosein, H; Le, J; Patel, G; Simpson, DJ; Sherborne, B; Thomas, PS; Suzuki, N; Takimoto-Kamimura, M; Kataoka, K Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach. J Med Chem 55:6700-15 (2012) [PubMed] Article
More Info.:
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Human
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Inhibitor
Name:
BDBM50395285
Synonyms:
CHEMBL2163997
Type:
Small organic molecule
Emp. Form.:
C19H19ClFN7
Mol. Mass.:
399.852
SMILES:
N[C@H]1CC[C@@H](CC1)Nc1cc(Nc2ccc(F)c(Cl)c2)n2ncc(C#N)c2n1 |r,wU:4.7,wD:1.0,(14.04,-16.11,;12.7,-16.87,;11.37,-16.1,;10.03,-16.86,;10.03,-18.39,;11.36,-19.17,;12.69,-18.41,;8.69,-19.16,;7.36,-18.39,;7.36,-16.85,;6.03,-16.07,;6.04,-14.53,;7.37,-13.76,;7.37,-12.23,;8.7,-11.46,;10.04,-12.23,;11.37,-11.46,;10.03,-13.77,;11.36,-14.55,;8.7,-14.54,;4.7,-16.84,;3.23,-16.36,;2.32,-17.61,;3.23,-18.87,;2.76,-20.34,;2.28,-21.8,;4.7,-18.39,;6.03,-19.15,)|