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Target
MAP kinase-activated protein kinase 2
Ligand
BDBM50395291
Substrate
n/a
Meas. Tech.
ChEMBL_860552 (CHEMBL2167126)
IC50
7000±n/a nM
Citation
 Kosugi, T; Mitchell, DR; Fujino, A; Imai, M; Kambe, M; Kobayashi, S; Makino, H; Matsueda, Y; Oue, Y; Komatsu, K; Imaizumi, K; Sakai, Y; Sugiura, S; Takenouchi, O; Unoki, G; Yamakoshi, Y; Cunliffe, V; Frearson, J; Gordon, R; Harris, CJ; Kalloo-Hosein, H; Le, J; Patel, G; Simpson, DJ; Sherborne, B; Thomas, PS; Suzuki, N; Takimoto-Kamimura, M; Kataoka, K Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach. J Med Chem 55:6700-15 (2012) [PubMed]  Article 
Target
Name:
MAP kinase-activated protein kinase 2
Synonyms:
MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45579.87
Organism:
Homo sapiens (Human)
Description:
P49137
Residue:
400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
  
Inhibitor
Name:
BDBM50395291
Synonyms:
CHEMBL2163619
Type:
Small organic molecule
Emp. Form.:
C19H24N6
Mol. Mass.:
336.4341
SMILES:
N[C@H]1CC[C@@H](CC1)Nc1cc(NCc2ccccc2)n2nccc2n1 |r,wU:4.7,wD:1.0,(26.73,-61.06,;25.39,-61.82,;24.06,-61.05,;22.72,-61.81,;22.72,-63.34,;24.05,-64.12,;25.38,-63.36,;21.39,-64.11,;20.05,-63.34,;20.05,-61.8,;18.72,-61.02,;18.73,-59.48,;17.4,-58.71,;17.4,-57.17,;18.74,-56.41,;18.74,-54.87,;17.41,-54.1,;16.07,-54.87,;16.07,-56.41,;17.39,-61.79,;15.92,-61.31,;15.01,-62.56,;15.92,-63.82,;17.39,-63.34,;18.72,-64.1,)|
Structure:
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