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Target
Neuropeptides B/W receptor type 1
Ligand
BDBM75886
Substrate
n/a
Meas. Tech.
ChEMBL_887068 (CHEMBL2213859)
IC50
680±n/a nM
Citation
 Urbano, M; Guerrero, M; Zhao, J; Velaparthi, S; Saldanha, SA; Chase, P; Wang, Z; Civelli, O; Hodder, P; Schaeffer, MT; Brown, S; Rosen, H; Roberts, E Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7). Bioorg Med Chem Lett 22:7135-41 (2012) [PubMed]  Article 
Target
Name:
Neuropeptides B/W receptor type 1
Synonyms:
GPR7 | NPBW1_HUMAN | NPBWR1 | neuropeptides B/W receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36111.82
Organism:
Homo sapiens (Human)
Description:
gi_119607128
Residue:
328
Sequence:
MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
  
Inhibitor
Name:
BDBM75886
Synonyms:
5-chloranyl-4-(4-ethylphenoxy)-2-(4-methylphenyl)pyridazin-3-one | 5-chloro-4-(4-ethylphenoxy)-2-(4-methylphenyl)-3-pyridazinone | 5-chloro-4-(4-ethylphenoxy)-2-(4-methylphenyl)pyridazin-3-one | 5-chloro-4-(4-ethylphenoxy)-2-(p-tolyl)pyridazin-3-one | SR-02000000354 | SR-02000000354-1 | cid_46172920
Type:
Small organic molecule
Emp. Form.:
C19H17ClN2O2
Mol. Mass.:
340.803
SMILES:
CCc1ccc(Oc2c(Cl)cnn(-c3ccc(C)cc3)c2=O)cc1
Structure:
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