Reaction Details Report a problem with these data
Target
Calcium/calmodulin-dependent protein kinase type II subunit delta
Ligand
BDBM2583
Substrate
n/a
Meas. Tech.
ChEMBL_470248 (CHEMBL950203)
IC50
1190±n/a nM
Citation
 Levy, DE; Wang, DX; Lu, Q; Chen, Z; Perumattam, J; Xu, YJ; Higaki, J; Dong, H; Liclican, A; Laney, M; Mavunkel, B; Dugar, S Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 2: SAR of the amine tether. Bioorg Med Chem Lett 18:2395-8 (2008) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit delta
Synonyms:
CAMK2D | CAMKD | CaM kinase II | CaM kinase II delta | CaMK-II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaMKII subunit delta) | KCC2D_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56419.78
Organism:
Homo sapiens (Human)
Description:
Q13557
Residue:
499
Sequence:
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
  
Inhibitor
Name:
BDBM2583
Synonyms:
3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione | BIM-4 | Bisindolyl deriv. 3 | Bisindolylmaleimide deriv. 5 | CHEMBL266487 | bis-indolylmaleimide deriv. 8a
Type:
Small organic molecule
Emp. Form.:
C20H13N3O2
Mol. Mass.:
327.3361
SMILES:
O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:5|
Structure:
Search PDB for entries with ligand similarity: