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Target
Histone deacetylase 1
Ligand
BDBM19135
Substrate
[3H]acetyl-labeled histones
Meas. Tech.
In Vitro Enzyme Inhibition Assay
pH
8±n/a
Temperature
310.15±n/a K
IC50
1270±n/a nM
Citation
 Itoh, Y; Suzuki, T; Kouketsu, A; Suzuki, N; Maeda, S; Yoshida, M; Nakagawa, H; Miyata, N Design, synthesis, structure-selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. J Med Chem 50:5425-38 (2007) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM19135
Synonyms:
CHEMBL209551 | tert-butyl N-[(1S)-1-(cyclohexylcarbamoyl)-6-sulfanylhexyl]carbamate | thiolate analogue, 17a
Type:
Small organic molecule
Emp. Form.:
C18H34N2O3S
Mol. Mass.:
358.539
SMILES:
CC(C)(C)OC(=O)N[C@@H](CCCCCS)C(=O)NC1CCCCC1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
[3H]acetyl-labeled histones
Synonyms:
n/a
Type:
Other Protein Type
Mol. Mass.:
358.43
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
3
Sequence:
NA