Reaction Details Report a problem with these data
Target
Tubulin beta chain
Ligand
BDBM50474300
Substrate
n/a
Meas. Tech.
ChEMBL_211691 (CHEMBL820473)
IC50
370±n/a nM
Citation
 Prinz, H; Ishii, Y; Hirano, T; Stoiber, T; Camacho Gomez, JA; Schmidt, P; Düssmann, H; Burger, AM; Prehn, JH; Günther, EG; Unger, E; Umezawa, K Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem 46:3382-94 (2003) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50474300
Synonyms:
CHEMBL116173
Type:
Small organic molecule
Emp. Form.:
C22H16O3
Mol. Mass.:
328.3606
SMILES:
[#6]-[#8]-c1ccc(\[#6]=[#6]-2\c3ccccc3-[#6](=O)-c3ccccc-23)cc1-[#8]
Structure:
Search PDB for entries with ligand similarity: