Reaction Details Report a problem with these data
Target
Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM50502339
Substrate
n/a
Meas. Tech.
ChEMBL_1807414 (CHEMBL4306773)
IC50
1300±n/a nM
Citation
Harris, PA; Marinis, JM; Lich, JD; Berger, SB; Chirala, A; Cox, JA; Eidam, PM; Finger, JN; Gough, PJ; Jeong, JU; Kang, J; Kasparcova, V; Leister, LK; Mahajan, MK; Miller, G; Nagilla, R; Ouellette, MT; Reilly, MA; Rendina, AR; Rivera, EJ; Sun, HH; Thorpe, JH; Totoritis, RD; Wang, W; Wu, D; Zhang, D; Bertin, J; Marquis, RW Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. ACS Med Chem Lett 10:857-862 (2019) [PubMed] Article
More Info.:
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP-1 | RIPK1_MOUSE | Receptor-interacting protein 1 | Receptor-interacting serine/threonine-protein kinase 1 | Rinp | Rinp | Rip | Ripk1 | Serine/threonine-protein kinase RIP
Type:
PROTEIN
Mol. Mass.:
74852.62
Organism:
Mus musculus
Description:
ChEMBL_116773
Residue:
656
Sequence:
MQPDMSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIVEAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEEDVASLKKEYPDQSPVLQRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLQMGPVEESWFSSSPEYPQDENDRSVQAKLQEEASYHAFGIFAEKQTKPQPRQNEAYNREEERKRRVSHDPFAQQRARENIKSAGARGHSDPSTTSRGIAVQQLSWPATQTVWNNGLYNQHGFGTTGTGVWYPPNLSQMYSTYKTPVPETNIPGSTPTMPYFSGPVADDLIKYTIFNSSGIQIGNHNYMDVGLNSQPPNNTCKEESTSRHQAIFDNTTSLTDEHLNPIRENLGRQWKNCARKLGFTESQIDEIDHDYERDGLKEKVYQMLQKWLMREGTKGATVGKLAQALHQCCRIDLLNHLIRASQS