Reaction Details
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Report a problem with these dataTarget
Cathepsin K
Ligand
BDBM50098579
Substrate
n/a
Meas. Tech.
ChEMBL_216705 (CHEMBL820317)
Ki
2.3±n/a nM
Citation
Marquis, RW; Ru, Y; LoCastro, SM; Zeng, J; Yamashita, DS; Oh, HJ; Erhard, KF; Davis, LD; Tomaszek, TA; Tew, D; Salyers, K; Proksch, J; Ward, K; Smith, B; Levy, M; Cummings, MD; Haltiwanger, RC; Trescher, G; Wang, B; Hemling, ME; Quinn, CJ; Cheng, HY; Lin, F; Smith, WW; Janson, CA; Zhao, B; McQueney, MS; D'Alessio, K; Lee, CP; Marzulli, A; Dodds, RA; Blake, S; Hwang, SM; James, IE; Gress, CJ; Bradley, BR; Lark, MW; Gowen, M; Veber, DF Azepanone-based inhibitors of human and rat cathepsin K. J Med Chem 44:1380-95 (2001) [PubMed] Article More Info.:
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
Inhibitor
Name:
BDBM50098579
Synonyms:
CHEMBL29483 | {1-[3-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-oxo-pyrrolidine-1-carbonyl]-3-methyl-butyl}-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C32H42N4O7
Mol. Mass.:
594.6985
SMILES:
CC(C)C[C@@H](NC(=O)OCc1ccccc1)C(=O)NC1CN(CC1=O)C(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
Structure:
