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Target
Heat sensitive channel TRPV3
Ligand
BDBM50548384
Substrate
n/a
Meas. Tech.
ChEMBL_2022061 (CHEMBL4675874)
EC50
4600±n/a nM
Citation
 Chianese, G; Lopatriello, A; Schiano-Moriello, A; Caprioglio, D; Mattoteia, D; Benetti, E; Ciceri, D; Arnoldi, L; De Combarieu, E; Vitale, RM; Amodeo, P; Appendino, G; De Petrocellis, L; Taglialatela-Scafati, O Cannabitwinol, a Dimeric Phytocannabinoid from Hemp,  J Nat Prod 83:2727-2736 (2020) [PubMed]  Article 
Target
Name:
Heat sensitive channel TRPV3
Synonyms:
Heat sensitive channel TRPV3
Type:
PROTEIN
Mol. Mass.:
90273.53
Organism:
Rattus norvegicus
Description:
ChEMBL_116972
Residue:
791
Sequence:
MKAHPKEMVPLMGKRTTAPGGNPAVLTEKRPADLTPTKKSAHFFLEIEGFEPNPTVTKTSPPIFSKPMDSNIRQCLSGNCDDMDSPQSPQDDVTETPSNPNSPSANLAKEEQRQKKKRLKKCIFAAVSEGCVRELRELLQDLQELCRRRRGLDASDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILGREIKEKPLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEIIVYNTNIDNRHEVLTLEPLHTLLHMKWKKFAKYMFFLSFCFYFSYNITLTLVSYYRPREGEALPHPLALTHKMSWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVIFGQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYILFLLGFGVALASLIEKCSKDKKDCSSYGSFSDAVLELFKLTIGLGGLNIQQNSTYPILFLFLLITYVILTFVLLLNMLIALMGETAENVSKESERIWRLQRARTTLEFEKMLPEWLRSRFRMGELCKVADEDFRLCLRINEVKWTEWKTHVSFLNEDPGPIRRTADSNKIQDSSRSNSKTTLYAFDELDEFPETSV
  
Inhibitor
Name:
BDBM50548384
Synonyms:
CHEMBL4762439
Type:
Small organic molecule
Emp. Form.:
C43H60O4
Mol. Mass.:
640.9341
SMILES:
CCCCCc1cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c(O)c1Cc1c(CCCCC)cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c1O |r,t:11,38|
Structure:
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