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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM50560628
Substrate
n/a
Meas. Tech.
ChEMBL_2072576 (CHEMBL4728110)
IC50
280±n/a nM
Citation
 Keith, JM; Jones, W; Pierce, JM; Seierstad, M; Palmer, JA; Webb, M; Karbarz, M; Scott, BP; Wilson, SJ; Luo, L; Wennerholm, M; Chang, L; Rizzolio, M; Rynberg, R; Chaplan, S; Guy Breitenbucher, J Heteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM50560628
Synonyms:
CHEMBL4787317
Type:
Small organic molecule
Emp. Form.:
C27H26ClN7O2
Mol. Mass.:
515.994
SMILES:
[H][C@]12CCN(C(=O)Nc3ccc(nc3)-n3nccn3)[C@@]1([H])CN(Cc1cccc(Oc3ccc(Cl)cc3)c1)C2 |r|
Structure:
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