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Target
Prothrombin
Ligand
BDBM50127496
Substrate
n/a
Meas. Tech.
ChEMBL_208505 (CHEMBL811978)
Ki
440000±n/a nM
Citation
 Sagi, K; Nakagawa, T; Yamanashi, M; Makino, S; Takahashi, M; Takayanagi, M; Takenaka, K; Suzuki, N; Oono, S; Kataoka, N; Ishikawa, K; Shima, S; Fukuda, Y; Kayahara, T; Takehana, S; Shima, Y; Tashiro, K; Yamamoto, H; Yoshimoto, R; Iwata, S; Tsuji, T; Sakurai, K; Shoji, M Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-substituted-4-amidinophenyl)pyruvic and -propionic acids. J Med Chem 46:1845-57 (2003) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50127496
Synonyms:
CHEMBL51796 | N-[2-(3-Carbamimidoyl-phenoxy)-ethyl]-4-[1-(1-imino-ethyl)-piperidin-4-yloxy]-benzamide
Type:
Small organic molecule
Emp. Form.:
C23H29N5O3
Mol. Mass.:
423.5081
SMILES:
CC(=N)N1CCC(CC1)Oc1ccc(cc1)C(=O)NCCOc1cccc(c1)C(N)=N
Structure:
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