Reaction Details Report a problem with these data
Target
Immunoglobulin lambda variable 6-57
Ligand
BDBM50576219
Substrate
n/a
Meas. Tech.
ChEMBL_2126712 (CHEMBL4836057)
EC50
25±n/a nM
Citation
 Yan, NL; Santos-Martins, D; Nair, R; Chu, A; Wilson, IA; Johnson, KA; Forli, S; Morgan, GJ; Petrassi, HM; Kelly, JW Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design. J Med Chem 64:6273-6299 (2021) [PubMed]  Article 
Target
Name:
Immunoglobulin lambda variable 6-57
Synonyms:
IGLV6-57 | Ig lambda chain V-VI region AR | Ig lambda chain V-VI region EB4 | Ig lambda chain V-VI region NIG-48 | Ig lambda chain V-VI region SUT | Ig lambda chain V-VI region WLT | Immunoglobulin lambda variable 6-57 | LV657_HUMAN
Type:
PROTEIN
Mol. Mass.:
12561.55
Organism:
Homo sapiens
Description:
ChEMBL_120180
Residue:
117
Sequence:
MAWAPLLLTLLAHCTGSWANFMLTQPHSVSESPGKTVTISCTGSSGSIASNYVQWYQQRPGSAPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSN
  
Inhibitor
Name:
BDBM50576219
Synonyms:
CHEMBL4856046
Type:
Small organic molecule
Emp. Form.:
C33H34N6O4
Mol. Mass.:
578.6609
SMILES:
C[C@H](Oc1ccc2c(C)c(CCN3CC4(CCN(CC4)c4nccn5ccnc45)NC3=O)c(=O)oc2c1)c1ccccc1 |r|
Structure:
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