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Target
Integrase
Ligand
BDBM50187759
Substrate
n/a
Meas. Tech.
ChEMBL_378064 (CHEMBL869770)
IC50
190±n/a nM
Citation
 Jin, H; Cai, RZ; Schacherer, L; Jabri, S; Tsiang, M; Fardis, M; Chen, X; Chen, JM; Kim, CU Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors. Bioorg Med Chem Lett 16:3989-92 (2006) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50187759
Synonyms:
7-(4-fluorobenzyl)-9-hydroxy-8-oxo-N-(pyridin-2-ylmethyl)-7,8-dihydro-6H-pyrrolo[3,4-g]quinoline-5-carboxamide | CHEMBL211110
Type:
Small organic molecule
Emp. Form.:
C25H19FN4O3
Mol. Mass.:
442.4418
SMILES:
Oc1c2C(=O)N(Cc3ccc(F)cc3)Cc2c(C(=O)NCc2ccccn2)c2cccnc12
Structure:
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