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Target
Proteinase-activated receptor 1
Ligand
BDBM50212449
Substrate
n/a
Meas. Tech.
ChEMBL_447297 (CHEMBL896330)
IC50
3139±n/a nM
Citation
 Clasby, MC; Chackalamannil, S; Czarniecki, M; Doller, D; Eagen, K; Greenlee, WJ; Lin, Y; Tagat, JR; Tsai, H; Xia, Y; Ahn, HS; Agans-Fantuzzi, J; Boykow, G; Chintala, M; Hsieh, Y; McPhail, AT Himbacine derived thrombin receptor antagonists: discovery of a new tricyclic core. Bioorg Med Chem Lett 17:3647-51 (2007) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50212449
Synonyms:
(3S,3aS,4S,9aR,E)-4-(2-(6-methoxyquinolin-2-yl)vinyl)-3-methyl-3a,4,9,9a-tetrahydronaphtho[2,3-c]furan-1(3H)-one | CHEMBL234688
Type:
Small organic molecule
Emp. Form.:
C25H23NO3
Mol. Mass.:
385.455
SMILES:
COc1ccc2nc(\C=C\[C@H]3[C@@H]4[C@H](C)OC(=O)[C@@H]4Cc4ccccc34)ccc2c1
Structure:
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