Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50222145
Substrate
n/a
Meas. Tech.
ChEMBL_449847 (CHEMBL897911)
EC50
3170±n/a nM
Citation
Hernández, AS; Cheng, PT; Musial, CM; Swartz, SG; George, RJ; Grover, G; Slusarchyk, D; Seethala, RK; Smith, M; Dickinson, K; Giupponi, L; Longhi, DA; Flynn, N; Murphy, BJ; Gordon, DA; Biller, SA; Robl, JA; Tino, JA Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues. Bioorg Med Chem Lett 17:5928-33 (2007) [PubMed] Article
More Info.:
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
Inhibitor
Name:
BDBM50222145
Synonyms:
CHEMBL237060 | methyl 2-(5-((S)-1-(2-amino-2-methylpropanamido)-2-(benzyloxy)ethyl)-2H-tetrazol-2-yl)-2-phenylacetate
Type:
Small organic molecule
Emp. Form.:
C23H28N6O4
Mol. Mass.:
452.5062
SMILES:
COC(=O)C(c1ccccc1)n1nnc(n1)[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N |w:4.11|