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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50267392
Substrate
n/a
Meas. Tech.
ChEMBL_562970 (CHEMBL1015369)
IC50
145000±n/a nM
Citation
 Lainé, DI; McCleland, B; Thomas, S; Neipp, C; Underwood, B; Dufour, J; Widdowson, KL; Palovich, MR; Blaney, FE; Foley, JJ; Webb, EF; Luttmann, MA; Burman, M; Belmonte, K; Salmon, M Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists. J Med Chem 52:2493-505 (2009) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM50267392
Synonyms:
2-(1-Azabicyclo[2.2.2]oct-3-yl)-1,1-diphenylethanol | CHEMBL500306
Type:
Small organic molecule
Emp. Form.:
C21H26NO
Mol. Mass.:
308.4367
SMILES:
OC(CC1C[NH+]2CCC1CC2)(c1ccccc1)c1ccccc1 |(-5.84,-18.12,;-5.06,-19.46,;-6.4,-20.23,;-7.74,-19.46,;-7.74,-17.9,;-9.09,-17.12,;-10.42,-17.9,;-10.42,-19.46,;-9.09,-20.23,;-8.43,-18.93,;-9.72,-18.3,;-3.74,-18.68,;-2.39,-19.44,;-1.07,-18.65,;-1.08,-17.11,;-2.44,-16.36,;-3.76,-17.14,;-4.3,-20.79,;-5.08,-22.11,;-4.32,-23.44,;-2.79,-23.44,;-2.02,-22.11,;-2.78,-20.79,)|
Structure:
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