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Found 655 with Last Name = 'widdowson' and Initial = 'kl'
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50267614(4-[Hydroxy(diphenyl)methyl]-1-{2-[(phenylmethyl)ox...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]N-methyl scopalamine from human cloned muscarinic M3 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381654(CHEMBL2023764)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381654(CHEMBL2023764)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50267573(4-[Hydroxy(diphenyl)methyl]-1-[3-(phenyloxy)propyl...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]N-methyl scopalamine from human cloned muscarinic M3 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50267614(4-[Hydroxy(diphenyl)methyl]-1-{2-[(phenylmethyl)ox...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]N-methyl scopalamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50267614(4-[Hydroxy(diphenyl)methyl]-1-{2-[(phenylmethyl)ox...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]N-methyl scopalamine from human cloned muscarinic M1 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381654(CHEMBL2023764)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M3 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50267573(4-[Hydroxy(diphenyl)methyl]-1-[3-(phenyloxy)propyl...)
Affinity DataKi:  0.640nMAssay Description:Displacement of [3H]N-methyl scopalamine from human cloned muscarinic M1 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50267573(4-[Hydroxy(diphenyl)methyl]-1-[3-(phenyloxy)propyl...)
Affinity DataKi:  0.940nMAssay Description:Displacement of [3H]N-methyl scopalamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349203(CHEMBL1807698)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant cathepsin S using Ac-KQLR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349197(CHEMBL1807647)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant cathepsin S using Ac-KQLR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349198(CHEMBL1807649)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of human recombinant cathepsin L using Z-LR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349205(CHEMBL1807700)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of human recombinant cathepsin S using Ac-KQLR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349196(CHEMBL1807646)
Affinity DataIC50:  0.760nMAssay Description:Inhibition of human recombinant cathepsin S using Ac-KQLR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349198(CHEMBL1807649)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant cathepsin K using z-LR-AFC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223976(8,8-dimethyl-3-(thiophen-3-yl-thiophen-3-ylmethyl-...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349203(CHEMBL1807698)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant cathepsin L using Z-LR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349204(CHEMBL1807699)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant cathepsin S using Ac-KQLR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349197(CHEMBL1807647)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant cathepsin L using Z-LR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349199(CHEMBL1807650)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant cathepsin S using Ac-KQLR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349206(CHEMBL1807702)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant cathepsin S using Ac-KQLR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349207(CHEMBL1807703)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant cathepsin S using Ac-KQLR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223976(8,8-dimethyl-3-(thiophen-3-yl-thiophen-3-ylmethyl-...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349202(CHEMBL1807697)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant cathepsin S using Ac-KQLR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223964(3-(benzyl-thiophen-3-yl-carbamoyloxy)-8,8-dimethyl...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223964(3-(benzyl-thiophen-3-yl-carbamoyloxy)-8,8-dimethyl...)
Affinity DataIC50:  2.10nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223990(8,8-dimethyl-3-(phenyl-thiophen-2-ylmethyl-carbamo...)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223990(8,8-dimethyl-3-(phenyl-thiophen-2-ylmethyl-carbamo...)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223981(8,8-dimethyl-3-(phenyl-thiophen-3-ylmethyl-carbamo...)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223991(3-(benzyl-thiophen-2-yl-carbamoyloxy)-8,8-dimethyl...)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223981(8,8-dimethyl-3-(phenyl-thiophen-3-ylmethyl-carbamo...)
Affinity DataIC50:  2.80nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349198(CHEMBL1807649)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human recombinant cathepsin S using Ac-KQLR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100036((S)-2-(2,4-Dimethyl-benzoylamino)-3-(4-nitro-pheny...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223991(3-(benzyl-thiophen-2-yl-carbamoyloxy)-8,8-dimethyl...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349195(CHEMBL1807645)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human recombinant cathepsin L using Z-LR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223993(8,8-dimethyl-3-[(3-methyl-thiophen-2-ylmethyl)-phe...)
Affinity DataIC50:  3.80nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50193985(3-{[[(2-bromophenyl)amino](cyanoimino)methyl]amino...)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]IL8 from CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223980(3-(benzyl-phenyl-carbamoyloxy)-8,8-dimethyl-8-azon...)
Affinity DataIC50:  4.5nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223980(3-(benzyl-phenyl-carbamoyloxy)-8,8-dimethyl-8-azon...)
Affinity DataIC50:  4.60nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349199(CHEMBL1807650)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human recombinant cathepsin K using z-LR-AFC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349196(CHEMBL1807646)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human recombinant cathepsin L using Z-LR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349195(CHEMBL1807645)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human recombinant cathepsin S using Ac-KQLR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50193979(3-{[[(2-bromophenyl)amino](cyanoimino)methyl]amino...)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]IL8 from CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50:  5nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing Eotaxin radioligand,using [Ca2+] mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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