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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50267390
Substrate
n/a
Meas. Tech.
ChEMBL_562970 (CHEMBL1015369)
IC50
1104000±n/a nM
Citation
 Lainé, DI; McCleland, B; Thomas, S; Neipp, C; Underwood, B; Dufour, J; Widdowson, KL; Palovich, MR; Blaney, FE; Foley, JJ; Webb, EF; Luttmann, MA; Burman, M; Belmonte, K; Salmon, M Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists. J Med Chem 52:2493-505 (2009) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM50267390
Synonyms:
3-(hydroxydiphenylmethyl)-1-azoniabicyclo[2.2.2]octane bromide | CHEMBL515462
Type:
Small organic molecule
Emp. Form.:
C20H24NO
Mol. Mass.:
294.4101
SMILES:
OC(C1C[NH+]2CCC1CC2)(c1ccccc1)c1ccccc1 |(9.93,.18,;9.15,-1.16,;7.82,-.39,;7.82,1.17,;6.47,1.95,;5.14,1.17,;5.14,-.39,;6.47,-1.16,;7.13,.14,;5.84,.77,;8.39,-2.5,;6.85,-2.5,;6.08,-3.84,;6.86,-5.17,;8.41,-5.16,;9.17,-3.82,;10.48,-1.93,;10.47,-3.46,;11.79,-4.23,;13.12,-3.47,;13.12,-1.93,;11.8,-1.17,)|
Structure:
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