Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50029703
Substrate
n/a
Meas. Tech.
ChEBML_86695
KOFF
0.000012 s-1
KON
44500 M-1s-1
Citation
Hlasta, DJ; Bell, MR; Court, JJ; Cundy, KC; Desai, RC; Ferguson, EW; Gordon, RJ; Kumar, V; Maycock, AL; Subramanyam, C; Dunlap, RP; Eiff, SL; Franke, CA; Mura, AJ; Rowlands, AG The design of potent and stable benzisothiazolone inhibitors of human leukocyte elastase Bioorg Med Chem Lett 5:331-336 (1995) Article
More Info.:
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
Inhibitor
Name:
BDBM50029703
Synonyms:
4-Isopropyl-6-methoxy-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one | CHEMBL98422 | WIN-63395
Type:
Small organic molecule
Emp. Form.:
C19H19N5O4S2
Mol. Mass.:
445.515
SMILES:
COc1cc2c(C(=O)N(CSc3nnnn3-c3ccccc3)S2(=O)=O)c(c1)C(C)C