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Target
Dipeptidyl peptidase 2
Ligand
BDBM50336806
Substrate
n/a
Meas. Tech.
ChEMBL_760119 (CHEMBL1810496)
IC50
20000±n/a nM
Citation
 Maezaki, H; Banno, Y; Miyamoto, Y; Moritoh, Y; Moritou, Y; Asakawa, T; Kataoka, O; Takeuchi, K; Suzuki, N; Ikedo, K; Kosaka, T; Sasaki, M; Tsubotani, S; Tani, A; Funami, M; Yamamoto, Y; Tawada, M; Aertgeerts, K; Yano, J; Oi, S Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554. Bioorg Med Chem 19:4482-98 (2011) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 2
Synonyms:
DPP2_RAT | Dipeptidyl peptidase II | Dpp2 | Dpp7
Type:
PROTEIN
Mol. Mass.:
55100.60
Organism:
Rattus norvegicus
Description:
ChEMBL_718679
Residue:
500
Sequence:
MGLHPCSPVDHGVPSWVLVLLLTLGLCSLQATADSVLDPDFRENYFEQYMDHFNFESFSNKTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSLANNSGFIVELAAQQEALLVFAEHRYYGKSLPFGVQSTQRGYTQLLTVEQALADFAVLLQALRHNLGVQDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVIAVAGLGNPDQFFRDVTADFYGQSPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSLSSPKDLTQLFGFARNAFTVLAMMDYPYPTNFLGPLPANPVKVGCERLLSEGQRIMGLRALAGLVYNSSGMEPCFDIYQMYQSCADPTGCGTGSNARAWDYQACTEINLTFDSNNVTDMFPEIPFSDELRQQYCLDTWGVWPRPDWLQTSFWGGDLKAASNIIFSNGDLDPWAGGGIQRNLSTSIIAVTIQGGAHHLDLRASNSEDPPSVVEVRKLEATLIREWVAAARLKQPAEAQWPGPK
  
Inhibitor
Name:
BDBM50336806
Synonyms:
1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-yl)piperazine-2,5-dione dihydrochloride | CHEMBL1672113
Type:
Small organic molecule
Emp. Form.:
C25H28N4O2
Mol. Mass.:
416.5154
SMILES:
CC(C)Cc1nc2ccc(cc2c(-c2ccc(C)cc2)c1CN)N1CC(=O)NCC1=O
Structure:
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