Reaction Details Report a problem with these data
Target
Histone deacetylase 2b
Ligand
BDBM50166164
Substrate
n/a
Meas. Tech.
ChEMBL_305568 (CHEMBL827162)
IC50
22000±n/a nM
Citation
 Mai, A; Massa, S; Pezzi, R; Simeoni, S; Rotili, D; Nebbioso, A; Scognamiglio, A; Altucci, L; Loidl, P; Brosch, G Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides. J Med Chem 48:3344-53 (2005) [PubMed]  Article 
Target
Name:
Histone deacetylase 2b
Synonyms:
Histone deacetylase HD2
Type:
PROTEIN
Mol. Mass.:
30785.07
Organism:
Zea mays
Description:
ChEMBL_87549
Residue:
286
Sequence:
MEVGGQEVKPGATVSCKVGDGLVIHLSQAALGESKKASENAILSVNIDDKKLVLGTLSVEKHPQISCDLVFDKDFELPHNSKTRSVFFRGYKSPVPLFESNSGEDSSDEELKTDQIPLQNNEIKISAAKVPAKDDDDDVFIILAMMMMIYSSDDDDDDFTTSDSDNEMSEEDDSSDEDEMSEEDDSSDEDEMSGGADPSDDSSDESGSEHTSAPKKTDVVVGKKRAIKAEAPYGKKAKSEQSSQKTGDKASTSHPAKQSIKTPADKSRKTPTADKKSPKSGSHGCK
  
Inhibitor
Name:
BDBM50166164
Synonyms:
(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1Hpyrrol-2-yl)-N-hydroxyacrylamide | (E)-3-{4-[3-(3-Fluoro-phenyl)-3-oxo-propenyl]-1-methyl-1H-pyrrol-2-yl}-N-hydroxy-acrylamide | 3-(4-(3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide | CHEMBL191089
Type:
Small organic molecule
Emp. Form.:
C17H15FN2O3
Mol. Mass.:
314.311
SMILES:
Cn1cc(\C=C\C(=O)c2cccc(F)c2)cc1\C=C\C(=O)NO
Structure:
Search PDB for entries with ligand similarity: