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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50401889
Substrate
n/a
Meas. Tech.
ChEMBL_886297 (CHEMBL2212340)
IC50
417.9±n/a nM
Citation
 Jin, Q; Davis, RS; Bullion, AM; Jin, J; Wang, Y; Widdowson, KL; Palovich, MR; Foley, JJ; Schmidt, DB; Buckley, PT; Webb, EF; Salmon, M; Belmonte, KE; Sarau, HM; Busch-Petersen, J Tyrosine urea muscarinic acetylcholine receptor antagonists: achiral quaternary ammonium groups. Bioorg Med Chem Lett 22:7087-91 (2012) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50401889
Synonyms:
CHEMBL2206607
Type:
Small organic molecule
Emp. Form.:
C33H40ClN4O5
Mol. Mass.:
608.147
SMILES:
CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCC2)cc1 |r|
Structure:
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