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Target
Histamine H4 receptor
Ligand
BDBM50127267
Substrate
n/a
Meas. Tech.
ChEMBL_1522301 (CHEMBL3630724)
Ki
1140±n/a nM
Citation
 Kaminska, K; Ziemba, J; Ner, J; Schwed, JS; Lazewska, D; Wiecek, M; Karcz, T; Olejarz, A; Latacz, G; Kuder, K; Kottke, T; Zygmunt, M; Sapa, J; Karolak-Wojciechowska, J; Stark, H; Kiec-Kononowicz, K (2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands. Eur J Med Chem 103:238-51 (2015) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50127267
Synonyms:
CHEMBL3628046
Type:
Small organic molecule
Emp. Form.:
C16H19BrN6
Mol. Mass.:
375.266
SMILES:
CN1CCN(CC1)c1nc(N)nc(\C=C\c2cccc(Br)c2)n1
Structure:
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