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Target
Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM50159511
Substrate
n/a
Meas. Tech.
ChEMBL_1569444 (CHEMBL3789106)
IC50
400±n/a nM
Citation
 Harris, PA; King, BW; Bandyopadhyay, D; Berger, SB; Campobasso, N; Capriotti, CA; Cox, JA; Dare, L; Dong, X; Finger, JN; Grady, LC; Hoffman, SJ; Jeong, JU; Kang, J; Kasparcova, V; Lakdawala, AS; Lehr, R; McNulty, DE; Nagilla, R; Ouellette, MT; Pao, CS; Rendina, AR; Schaeffer, MC; Summerfield, JD; Swift, BA; Totoritis, RD; Ward, P; Zhang, A; Zhang, D; Marquis, RW; Bertin, J; Gough, PJ DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. J Med Chem 59:2163-78 (2016) [PubMed]  Article 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75926.99
Organism:
Homo sapiens (Human)
Description:
Q13546
Residue:
671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
  
Inhibitor
Name:
BDBM50159511
Synonyms:
CHEMBL3786162
Type:
Small organic molecule
Emp. Form.:
C22H18N2O4
Mol. Mass.:
374.3893
SMILES:
O=C(N[C@H]1COc2ccccc2NC1=O)c1cccc(Oc2ccccc2)c1 |r|
Structure:
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