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TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM87369(US9694016, 704 | US10245267, Example 704 | US10709...)
Affinity DataIC50: 0.0200nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM87369(US9694016, 704 | US10245267, Example 704 | US10709...)
Affinity DataIC50: 0.0200nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM25619((1Z)-5-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]...)
Affinity DataIC50: 0.0200nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM87369(US9694016, 704 | US10245267, Example 704 | US10709...)
Affinity DataIC50: 0.0200nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50006650(CHEMBL526479)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of BRAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM25636((1Z)-5-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1H-pyr...)
Affinity DataIC50: 0.0300nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50481591(CHEMBL5289891)
Affinity DataIC50: 0.0340nMAssay Description:Inhibition of B-RAF V600E mutant (unknown origin) expressed in HEK293 cells in presence of tracer incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM25625((1S,3R)-3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H...)
Affinity DataIC50: 0.0400nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM435718(US10570155, Compound 2II | US11332479, Compound 2I...)
Affinity DataIC50: 0.0400nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM435718(US10570155, Compound 2II | US11332479, Compound 2I...)
Affinity DataIC50: 0.0400nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM25629(3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataIC50: 0.0500nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM554464(US11332479, Compound 50III)
Affinity DataIC50: 0.0500nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM186829(US9670203, Compound 1.21)
Affinity DataIC50: 0.0660nMAssay Description:Inhibition of B-RAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50585092(CHEMBL5087577)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50580082(CHEMBL5079215)
Affinity DataKi: <0.0800nMAssay Description:Inhibition of BRAF (unknown origin) (416 to 766) inactive MAP2K1 as substrate preincubated for 30 mins measured after 90 mins by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50580083(CHEMBL5094268)
Affinity DataKi: <0.0800nMAssay Description:Inhibition of BRAF (unknown origin) (416 to 766) inactive MAP2K1 as substrate preincubated for 30 mins measured after 90 mins by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM554470(US11332479, Compound 72IV)
Affinity DataIC50: 0.0800nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50580084(CHEMBL5075174)
Affinity DataKi: <0.0800nMAssay Description:Inhibition of BRAF (unknown origin) (416 to 766) inactive MAP2K1 as substrate preincubated for 30 mins measured after 90 mins by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50557770(CHEMBL4780060)
Affinity DataKi: <0.0800nMAssay Description:Inhibition of BRAF (unknown origin) (416 to 766) inactive MAP2K1 as substrate preincubated for 30 mins measured after 90 mins by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103683(US8563553, 108)
Affinity DataIC50: 0.0800nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50557775(CHEMBL4758903)
Affinity DataKi: <0.0800nMAssay Description:Inhibition of BRAF (unknown origin) (416 to 766) assessed as using inactive phosphorylated MAP2K1 substrate preincubated for 30 mins measured after 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103702(US8563553, 127)
Affinity DataIC50: 0.0800nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50557773(CHEMBL4778772)
Affinity DataKi: <0.0800nMAssay Description:Inhibition of BRAF (unknown origin) (416 to 766) assessed as using inactive phosphorylated MAP2K1 substrate preincubated for 30 mins measured after 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50557772(CHEMBL4775998)
Affinity DataKi: <0.0800nMAssay Description:Inhibition of BRAF (unknown origin) (416 to 766) assessed as using inactive phosphorylated MAP2K1 substrate preincubated for 30 mins measured after 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50580081(CHEMBL5094514)
Affinity DataKi: <0.0800nMAssay Description:Inhibition of BRAF (unknown origin) (416 to 766) inactive MAP2K1 as substrate preincubated for 30 mins measured after 90 mins by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50557770(CHEMBL4780060)
Affinity DataKi: <0.0800nMAssay Description:Inhibition of BRAF (unknown origin) (416 to 766) assessed as using inactive phosphorylated MAP2K1 substrate preincubated for 30 mins measured after 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM25626((1R,3R)-3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H...)
Affinity DataIC50: 0.0900nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50481593(CHEMBL5287468)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of B-Raf in human A-375 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103684(US8563553, 109)
Affinity DataIC50: 0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103629(US8563553, 54)
Affinity DataIC50: 0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103628(US8563553, 53)
Affinity DataIC50: 0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50026212(CHEMBL1276185)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103681(US8563553, 106)
Affinity DataIC50: 0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50139058(CHEMBL3752213)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) by lantha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103632(US8563553, 57)
Affinity DataIC50: 0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataKd:  0.100nMAssay Description:The assay is not in detail.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataKd:  0.100nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50026207(CHEMBL1276170)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50557771(CHEMBL4740241)
Affinity DataKi:  0.102nMAssay Description:Inhibition of BRAF (unknown origin) (416 to 766) assessed as using inactive phosphorylated MAP2K1 substrate preincubated for 30 mins measured after 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103677(US8563553, 102)
Affinity DataIC50: 0.110nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103699(US8563553, 124)
Affinity DataIC50: 0.110nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50330925(7-(2,6-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyc...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50557774(CHEMBL4776565)
Affinity DataKi:  0.120nMAssay Description:Inhibition of BRAF (unknown origin) (416 to 766) assessed as using inactive phosphorylated MAP2K1 substrate preincubated for 30 mins measured after 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103723(US8563553, 148)
Affinity DataIC50: 0.120nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50029085(CHEBI:83405 | GDC-0879 | CHEMBL525191)
Affinity DataKi:  0.130nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103680(US8563553, 105)
Affinity DataIC50: 0.130nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM25628(2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataIC50: 0.130nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103715(US8563553, 140)
Affinity DataIC50: 0.130nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50645270(CHEMBL5566280)
Affinity DataKi:  0.130nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103721(US8563553, 146)
Affinity DataIC50: 0.130nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

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