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TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50507483(CHEMBL4530379)
Affinity DataKi:  0.00230nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50125046(CHEMBL3623792)
Affinity DataKi:  0.0300nMAssay Description:Inhibition of beta-trypsin (unknown origin) using Bz-FVRpNA substrate by spectrophotometry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50124947(CHEMBL453539)
Affinity DataKi:  0.100nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50421510(CHEMBL239127)
Affinity DataKi:  0.100nMAssay Description:Compound was tested for inhibition of Sunflower beta-trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50125045(CHEMBL3623793)
Affinity DataKi:  0.160nMAssay Description:Inhibition of beta-trypsin (unknown origin) using Bz-FVRpNA substrate by spectrophotometry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50533536(CHEMBL4483694)
Affinity DataKi:  0.160nMAssay Description:Inhibition of trypsin (unknown origin) using Bz-FVRpNA as substrate incubated for 30 mins measured for 7 mins by morrison plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50124906(CHEMBL3623776)
Affinity DataKi:  0.700nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTrypsin-3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131988(2-[1-(Benzothiazole-2-carbonyl)-4-guanidino-butylc...)
Affinity DataIC50: 1nMAssay Description:Beta-Trypsin inhibitory activity of compound was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50459539(CHEMBL4206734)
Affinity DataIC50: 1nMAssay Description:Inhibition of trypsin (unknown origin) pre-incubated for 30 mins before N-Boc-FSR-AMC substrate addition and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTrypsin-3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50421510(CHEMBL239127)
Affinity DataKi:  1.10nMAssay Description:Compound was tested for inhibition of bovine beta trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50513213(CHEMBL3344303)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of trypsin (unknown origin) using Boc-Val-Pro-Arg-AMC as substrate preincubated with enzyme for 15 mins followed by addition of substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50513215(CHEMBL4561509)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of trypsin (unknown origin) using Boc-Val-Pro-Arg-AMC as substrate preincubated with enzyme for 15 mins followed by addition of substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTrypsin-3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131981(N-{[1-(Benzothiazole-2-carbonyl)-4-guanidino-butyl...)
Affinity DataIC50: 2nMAssay Description:Beta-Trypsin inhibitory activity of compound was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50110387(4-{2-[(S)-5-((S)-2,3-Dihydro-benzofuran-5-sulfonyl...)
Affinity DataKi:  2.5nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50513214(CHEMBL4586045)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of trypsin (unknown origin) using Boc-Val-Pro-Arg-AMC as substrate preincubated with enzyme for 15 mins followed by addition of substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50110389(4-{3-[(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamin...)
Affinity DataKi:  3.20nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50097624(3-(3-Carbamimidoyl-phenyl)-3H-[1,2,3]triazole-4-ca...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity towards human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50424712(Camostat Mesilate | Foipan | CAMOSTAT)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of trypsin (unknown origin) using Boc-Val-Pro-Arg-AMC as substrate preincubated with enzyme for 15 mins followed by addition of substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50514081(CHEMBL4471466)
Affinity DataKi:  3.60nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50514081(CHEMBL4471466)
Affinity DataKi:  3.60nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTrypsin-3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131976(1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataIC50: 4nMAssay Description:Beta-Trypsin inhibitory activity of compound was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetTrypsin-3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131984(1-Acetyl-azetidine-2-carboxylic acid [1-(benzothia...)
Affinity DataIC50: 5nMAssay Description:Beta-Trypsin inhibitory activity of compound was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50110393(5-{3-[(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamin...)
Affinity DataKi:  5.90nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50097626(CHEMBL160489 | CHEMBL332157 | 1-(3-Carbamimidoyl-p...)
Affinity DataKi:  6.40nMAssay Description:Binding affinity towards human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50507482(CHEMBL4531700)
Affinity DataKi:  6.90nMAssay Description:Inhibition of trypsin (unknown origin) using Bz-FVR-pNA as substrate preincubated for 30 mins followed by substrate addition and measured for 7 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50533535(CHEMBL4440685)
Affinity DataKi:  6.90nMAssay Description:Inhibition of trypsin (unknown origin) using Bz-FVRpNA as substrate incubated for 30 mins measured for 7 mins by morrison plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50110374(4-{3-[(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamin...)
Affinity DataKi:  7.60nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50125048(CHEMBL3623788)
Affinity DataKi:  8nMAssay Description:Inhibition of beta-trypsin (unknown origin) using Bz-FVRpNA substrate by spectrophotometry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTrypsin-3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131978(1-Benzyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataIC50: 8nMAssay Description:Beta-Trypsin inhibitory activity of compound was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50110391(4-[3-((S)-3-Benzenesulfonylamino-2-oxo-azepan-1-yl...)
Affinity DataKi:  8.30nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520867(CHEMBL4441346)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of human trypsin preincubated for 30 mins followed by substrate addition and measured for 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50110392(4-{3-[(S)-3-(3,4-Dimethoxy-benzenesulfonylamino)-2...)
Affinity DataKi:  12nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50110375(4-{3-[(S)-3-(Naphthalene-2-sulfonylamino)-2-oxo-az...)
Affinity DataKi:  12nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50096095(2-(3-Carbamimidoyl-phenyl)-2H-pyrazole-3-carboxyli...)
Affinity DataKi:  15nMAssay Description:Binding affinity towards human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM12751(CHEMBL152854 | 1-(3-carbamimidoylphenyl)-3-methyl-...)
Affinity DataKi:  16nMAssay Description:Inhibition of human trypsin using S-2222 as substrate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50110394([amino({[(4S)-4-carboxy-4-{2-[(3S)-3-({[2-(methoxy...)
Affinity DataKi:  16nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM12751(CHEMBL152854 | 1-(3-carbamimidoylphenyl)-3-methyl-...)
Affinity DataKi:  16nMAssay Description:Binding affinity towards human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520865(CHEMBL4469752)
Affinity DataIC50: 18nMAssay Description:Inhibition of human trypsin preincubated for 30 mins followed by substrate addition and measured for 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50110382([amino({[(4S)-4-carboxy-4-{2-[(3S)-2-oxo-3-(phenyl...)
Affinity DataKi:  18nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50072442({(3-Carbamimidoyl-phenyl)-[2-(2'-sulfamoyl-bipheny...)
Affinity DataKi:  19nMAssay Description:Inhibition of serine protease trypsin enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50110379(4-{3-[(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamin...)
Affinity DataKi:  20nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50087533(CHEMBL140072 | CHEMBL153611 | 3-(3-Carbamimidoyl-p...)
Affinity DataKi:  21nMAssay Description:Binding affinity towards human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50063581(CHEMBL3398612)
Affinity DataKi:  23nMAssay Description:Inhibition of human trypsin at 25 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  23nMAssay Description:Inhibition of human coagulation trypsin using N-benzoyl-Ile-Glu-(OH, OMe)-Gly-Arg-pNA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50097621(1-(3-Carbamimidoyl-phenyl)-1H-imidazole-2-carboxyl...)
Affinity DataKi:  26nMAssay Description:Binding affinity towards human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypsin-3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50449678(CHEMBL4164510)
Affinity DataKi:  26nMAssay Description:Competitive inhibition of recombinant human mesotrypsin using Z-GPR-MCA as substrate measured every 30 secs for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50097619(1-(3-Carbamimidoyl-phenyl)-4-methyl-1H-imidazole-2...)
Affinity DataKi:  27nMAssay Description:Binding affinity towards human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50513218(CHEMBL4451902)
Affinity DataIC50: 28nMAssay Description:Inhibition of trypsin (unknown origin) using Boc-Val-Pro-Arg-AMC as substrate preincubated with enzyme for 15 mins followed by addition of substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTrypsin-3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50449679(CHEMBL4167071)
Affinity DataKi:  28nMAssay Description:Competitive inhibition of recombinant human mesotrypsin using Z-GPR-MCA as substrate measured every 30 secs for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50507481(CHEMBL4564063)
Affinity DataKi:  31nMAssay Description:Inhibition of trypsin (unknown origin) using Bz-FVR-pNA as substrate preincubated for 30 mins followed by substrate addition and measured for 7 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
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