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Report error Found 236 of affinity data for UniProtKB/TrEMBL: O60911
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414641(CHEMBL554065)
Affinity DataIC50: 2nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414640(CHEMBL562844)
Affinity DataIC50: 3.16nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414638(CHEMBL549378)
Affinity DataIC50: 6.31nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414639(CHEMBL550872)
Affinity DataIC50: 6.31nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414642(CHEMBL549791)
Affinity DataIC50: 7.94nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50331557(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 16.6nMAssay Description:Inhibition of human cathepsin V by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414637(CHEMBL562915)
Affinity DataIC50: 19.9nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50602542(CHEMBL4594870)
Affinity DataIC50: 20.6nMAssay Description:Inhibition of human recombinant Cathepsin V assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414636(CHEMBL559880)
Affinity DataIC50: 25.1nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50331769((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human Cat VMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50165427([(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-car...)
Affinity DataIC50: 29nMAssay Description:Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50331555(N-(1-(1H-pyrazol-3-ylamino)-1,2-dioxopentan-3-yl)-...)
Affinity DataIC50: 29.5nMAssay Description:Inhibition of human cathepsin V by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50331556(2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-...)
Affinity DataIC50: 36.3nMAssay Description:Inhibition of human cathepsin V by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414643(CHEMBL557455)
Affinity DataIC50: 39.8nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414633(CHEMBL556436)
Affinity DataIC50: 63.1nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50602544(CHEMBL4594757)
Affinity DataIC50: 63.2nMAssay Description:Inhibition of human recombinant Cathepsin V assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50331768((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50: 69nMAssay Description:Inhibition of human Cat VMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM12311(SCH 503034 | (1R,5S)-N-[3-Amino-1-(cyclobutylmethy...)
Affinity DataIC50: 75nMAssay Description:Inhibition of human Cathepsin VMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50165424((S)-4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl (S)-1,...)
Affinity DataIC50: 79nMAssay Description:Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50331767(1-(4'-((S)-1-((S)-1-((S)-1-cyano-2-(4-cyano-2-fluo...)
Affinity DataIC50: 79nMAssay Description:Inhibition of human Cat VMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414644(CHEMBL555122)
Affinity DataIC50: 100nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50169493((S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50: 130nMAssay Description:Inhibition of 2 lM Cbz-Phe-Arg-AMC binding to human cathepsin V activity in fluorescence assay with 100 mM NaOAcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201701(cis-4-(2,3-dimethylphenoxy)-6-oxa-1-aza-bicyclo[3....)
Affinity DataIC50: 131nMAssay Description:Inhibition of human recombinant cathepsin VMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50: 140nMAssay Description:Inhibition of human Cathepsin V using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201700((1R,2S)-2-phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octan-...)
Affinity DataIC50: 158nMAssay Description:Inhibition of human recombinant cathepsin VMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414629(CHEMBL563471)
Affinity DataIC50: 158nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414635(CHEMBL564626)
Affinity DataIC50: 158nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM19783((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 170nMAssay Description:Inhibition of 2 lM Cbz-Phe-Arg-AMC binding to human cathepsin V activity in fluorescence assay with 100 mM NaOAcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50165423([(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-car...)
Affinity DataIC50: 180nMAssay Description:Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50602543(CHEMBL4598338)
Affinity DataIC50: 186nMAssay Description:Inhibition of human recombinant Cathepsin V assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50165426([(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-car...)
Affinity DataIC50: 190nMAssay Description:Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31977(Dipeptidyl nitrile inhibitor, 10)
Affinity DataIC50: 200nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31980(Dipeptidyl nitrile inhibitor, 13)
Affinity DataIC50: 200nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31992(Dipeptidyl nitrile inhibitor, 25)
Affinity DataIC50: 200nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620957(CHEMBL5430978)
Affinity DataIC50: 200nMAssay Description:Inhibition of human Cathepsin L2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31992(Dipeptidyl nitrile inhibitor, 25)
Affinity DataIC50: 200nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31988(Dipeptidyl nitrile inhibitor, 21)
Affinity DataIC50: 251nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50165428([(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-car...)
Affinity DataIC50: 290nMAssay Description:Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50165425([(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-car...)
Affinity DataIC50: 340nMAssay Description:Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50165420([(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-car...)
Affinity DataIC50: 390nMAssay Description:Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31972(Dipeptidyl nitrile inhibitor, 5)
Affinity DataIC50: 398nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31993(Dipeptidyl nitrile inhibitor, 26)
Affinity DataIC50: 398nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31993(Dipeptidyl nitrile inhibitor, 26)
Affinity DataIC50: 398nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50602545(CHEMBL4596647)
Affinity DataIC50: 419nMAssay Description:Inhibition of human recombinant Cathepsin V assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50519377(CHEMBL4438688)
Affinity DataIC50: 420nMAssay Description:Inhibition of recombinant human cathepsin V using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50169495([(S)-1-(2H-Pyrazol-3-ylaminooxalyl)-pentyl]-carbam...)
Affinity DataIC50: 430nMAssay Description:Inhibition of 2 lM Cbz-Phe-Arg-AMC binding to human cathepsin V activity in fluorescence assay with 100 mM NaOAcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50: 460nMAssay Description:Inhibition of human Cathepsin V using Z-Phe-Arg-aminomethylcoumarin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31989(Dipeptidyl nitrile inhibitor, 22)
Affinity DataIC50: 501nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31990(Dipeptidyl nitrile inhibitor, 23)
Affinity DataIC50: 501nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31991(Dipeptidyl nitrile inhibitor, 24)
Affinity DataIC50: 501nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
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