Compile Data Set for Download or QSAR
Report error Found 2161 of affinity data for UniProtKB/TrEMBL: O75469
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50251088(N-(1-benzyl-1H-benzo[d]imidazol-5-yl)-2,3,4,5,6-pe...)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human pregnane X receptor expressed in HGPXR reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50609814(CHEMBL5284539)
Affinity DataIC50: 1nMAssay Description:Inverse agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition of r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50251070(N-(1-benzyl-1H-benzo[d]imidazol-5-yl)-2,4,6-trimet...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human pregnane X receptor expressed in HGPXR reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50609809(CHEMBL5286515)
Affinity DataIC50: 1.60nMAssay Description:Inverse agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition of r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50240347((Z,Z,Z)-9,12,15-octadecatrienoic acid | cis,cis,ci...)
Affinity DataEC50:  2nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50226465(E-guggulsterone | pregna-4,17(20)-cis-diene-3,16-d...)
Affinity DataIC50: 2.40nMAssay Description:Inhibitory concentration against Pregnane X receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM21725((1S,2R,10R,11S,14Z,15S)-14-ethylidene-2,15-dimethy...)
Affinity DataIC50: 2.40nMAssay Description:Inhibitory concentration against Pregnane X receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM21670(N-[4-(1-cyclohexyl-2,2,2-trifluoro-1-hydroxyethyl)...)
Affinity DataIC50: 25nM EC50:  3nMpH: 8.0 T: 2°CAssay Description:Polylysine YiO imaging beads (Amersham, GE Healthcare) were coated with histidine-tagged WT PXR LBD. Nonspecific binding sites were blocked with BSA....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM769659(US20250282736, Compound M4)
Affinity DataIC50: 3nMAssay Description:PXR can be determined in an in vitro assay system. Such in vitro assay systems include assay such as the assays as described herein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM769646(US20250282736, Compound J1)
Affinity DataIC50: 3.80nMAssay Description:PXR can be determined in an in vitro assay system. Such in vitro assay systems include assay such as the assays as described herein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50609818(CHEMBL5277255)
Affinity DataIC50: 4nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50103611(CHEBI:31524 | DOPS | Droxidopa | L-DOPS)
Affinity DataEC50:  4nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM769561(US20250282736, Compound B26)
Affinity DataIC50: 4.40nMAssay Description:PXR can be determined in an in vitro assay system. Such in vitro assay systems include assay such as the assays as described herein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50560309(CHEMBL4785075)
Affinity DataEC50:  5nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50609814(CHEMBL5284539)
Affinity DataIC50: 6nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM769643(US20250282736, Compound I1)
Affinity DataIC50: 6.20nMAssay Description:PXR can be determined in an in vitro assay system. Such in vitro assay systems include assay such as the assays as described herein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM769562(US20250282736, Compound B27)
Affinity DataIC50: 6.20nMAssay Description:PXR can be determined in an in vitro assay system. Such in vitro assay systems include assay such as the assays as described herein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50609813(CHEMBL5281952)
Affinity DataIC50: 6.90nMAssay Description:Antagonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in rifamp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50609793(CHEMBL5290088)
Affinity DataIC50: 6.90nMAssay Description:Inverse agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition of r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50609810(CHEMBL5282848)
Affinity DataIC50: 7nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50609816(CHEMBL5285451)
Affinity DataIC50: 7nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM769644(US20250282736, Compound I2)
Affinity DataIC50: 7.20nMAssay Description:PXR can be determined in an in vitro assay system. Such in vitro assay systems include assay such as the assays as described herein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM769565(US20250282736, Compound B30)
Affinity DataIC50: 7.40nMAssay Description:PXR can be determined in an in vitro assay system. Such in vitro assay systems include assay such as the assays as described herein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM769566(US20250282736, Compound B31)
Affinity DataIC50: 7.5nMAssay Description:PXR can be determined in an in vitro assay system. Such in vitro assay systems include assay such as the assays as described herein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM769624(US20250282736, Compound F10)
Affinity DataIC50: 7.60nMAssay Description:PXR can be determined in an in vitro assay system. Such in vitro assay systems include assay such as the assays as described herein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM769636(US20250282736, Compound G12)
Affinity DataIC50: 7.60nMAssay Description:PXR can be determined in an in vitro assay system. Such in vitro assay systems include assay such as the assays as described herein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM769661(US20250282736, Compound M9)
Affinity DataIC50: 7.80nMAssay Description:PXR can be determined in an in vitro assay system. Such in vitro assay systems include assay such as the assays as described herein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM19993(CHEMBL62136 | [3H]T0901317 | T 0901317 | N-[4-(1,1...)
Affinity DataEC50:  8nMAssay Description:Transactivation of PXR in human HepG2 cells by receptor transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50463434(CHEMBL3781118)
Affinity DataEC50:  8nMAssay Description:Activation of human PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50251088(N-(1-benzyl-1H-benzo[d]imidazol-5-yl)-2,3,4,5,6-pe...)
Affinity DataEC50:  8.04nMAssay Description:Protection of human pregnane X receptor against proteolytic digestion in presence of trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50251070(N-(1-benzyl-1H-benzo[d]imidazol-5-yl)-2,4,6-trimet...)
Affinity DataEC50:  8.05nMAssay Description:Protection of human pregnane X receptor against proteolytic digestion in presence of trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50609819(CHEMBL5274748)
Affinity DataEC50:  8.10nMAssay Description:Agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as transcriptional activat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM769645(US20250282736, Compound I3)
Affinity DataIC50: 8.5nMAssay Description:PXR can be determined in an in vitro assay system. Such in vitro assay systems include assay such as the assays as described herein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50609818(CHEMBL5277255)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in rifamp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM429599(US10550091, No. LC-8 | US10947203, No. LC-8)
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM340691(US9771320, Example 5 | 1,1,1,3,3,3-hexafluoro-2-(4...)
Affinity DataEC50:  10nMAssay Description:Transactivation of PXR in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM429621(US10550091, No. LC-30 | US10947203, No. LC-30)
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM429599(US10550091, No. LC-8 | US10947203, No. LC-8)
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM21673(N-[4-(1,1,1,3,3,4,4,5,5,5-decafluoro-2-hydroxypent...)
Affinity DataIC50: 20nM EC50:  10nMpH: 8.0 T: 2°CAssay Description:Polylysine YiO imaging beads (Amersham, GE Healthcare) were coated with histidine-tagged WT PXR LBD. Nonspecific binding sites were blocked with BSA....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM429611(US10550091, No. LC-20 | US10947203, No. LC-20)
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM429627(US10550091, No. LC-36 | US10947203, No. LC-36)
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM429621(US10550091, No. LC-30 | US10947203, No. LC-30)
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM429611(US10550091, No. LC-20 | US10947203, No. LC-20)
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM429627(US10550091, No. LC-36 | US10947203, No. LC-36)
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM429626(US10550091, No. LC-35 | US10947203, No. LC-35)
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM429626(US10550091, No. LC-35 | US10947203, No. LC-35)
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50609819(CHEMBL5274748)
Affinity DataIC50: 11nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM769563(US20250282736, Compound B28)
Affinity DataIC50: 11.9nMAssay Description:PXR can be determined in an in vitro assay system. Such in vitro assay systems include assay such as the assays as described herein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM769570(US20250282736, Compound B35)
Affinity DataIC50: 12nMAssay Description:PXR can be determined in an in vitro assay system. Such in vitro assay systems include assay such as the assays as described herein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50609811(CHEMBL5288280)
Affinity DataIC50: 12nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
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