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TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550633(CHEMBL4763515)
Affinity DataIC50: 0.200nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50108997(CGP-71872 | CHEMBL1628548)
Affinity DataKd:  1nMAssay Description:Binding affinity to GABA-B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550634(CHEMBL4791366)
Affinity DataIC50: 1.20nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24184((3-aminopropyl)phosphinic acid | CHEMBL112203 | CG...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550631(CHEMBL4756657)
Affinity DataIC50: 2.40nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550632(CHEMBL4787614)
Affinity DataIC50: 4.90nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24185(CGP35024 | 3-Apmpa | CHEMBL112710 | (3-aminopropyl...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50108998(CHEMBL3600560)
Affinity DataEC50:  8.60nMAssay Description:Agonist activity at human recombinant GABA-B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50570461(CHEMBL4847170)
Affinity DataIC50: 13nMAssay Description:Agonist activity at human GABAB expressed in HEK293T cells co-transfected with human CaV2.2 channel assessed as inhibition of CaV2.2-mediated Ba2+ pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032964(4-Amino-3-(4-chloro-phenyl)-butyric acid | (R)-4-A...)
Affinity DataIC50: 15nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM430568(US10556914, Example 59)
Affinity DataEC50:  17nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24186(3-aminopropylphosphinic derivative, (S)-3 | CHEMBL...)
Affinity DataIC50: 18nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550638(CHEMBL4762233)
Affinity DataIC50: 19nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550636(CHEMBL4745449)
Affinity DataIC50: 19nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50570462(CHEMBL4856595)
Affinity DataIC50: 21nMAssay Description:Agonist activity at human GABAB expressed in HEK293T cells co-transfected with human CaV2.2 channel assessed as inhibition of CaV2.2-mediated Ba2+ pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550639(CHEMBL4740566)
Affinity DataIC50: 23nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM430588(US10556914, Example 82)
Affinity DataEC50:  23nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataIC50: 25nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24189(CHEMBL113304 | [(2S)-3-amino-2-hydroxypropyl](meth...)
Affinity DataIC50: 29nMAssay Description:Inhibition of [3H]CGP-27492 binding to cat Gamma-aminobutyric acid type B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM430603(US10556914, Example 105)
Affinity DataEC50:  33nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24182(4-amino-3-(4-chlorophenyl)butanoic acid | CHEMBL70...)
Affinity DataIC50: 35nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032958([3-Amino-2-(4-chloro-phenyl)-propyl]-phosphinic ac...)
Affinity DataIC50: 39nMAssay Description:Inhibition of [3H]baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM430581(US10556914, Example 73)
Affinity DataEC50:  39nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

LigandPNGBDBM430613(US10556914, Example 117)
Affinity DataEC50:  43nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

LigandPNGBDBM430577(US10556914, Example 68)
Affinity DataEC50:  48nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

LigandPNGBDBM430521(US10556914, Example 1 | N-(3-{5-[(1S)-1-(4-chlorop...)
Affinity DataEC50:  51nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

LigandPNGBDBM430615(US10556914, Example 119)
Affinity DataEC50:  56nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593659(CHEMBL5207265)
Affinity DataEC50:  64nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM430564(US10556914, Example 55)
Affinity DataEC50:  80nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593660(CHEMBL5170235)
Affinity DataEC50:  90nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593653(CHEMBL5185974)
Affinity DataEC50:  97nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM430551(US10556914, Example 39)
Affinity DataEC50:  105nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593654(CHEMBL5204436)
Affinity DataEC50:  142nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032971(CGP-35582 | (3-Amino-1-methyl-propyl)-methyl-phosp...)
Affinity DataIC50: 166nMAssay Description:Inhibition of [3H]CGP-27492 binding to cat Gamma-aminobutyric acid type B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593650(CHEMBL5169533)
Affinity DataEC50:  199nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24185(CGP35024 | 3-Apmpa | CHEMBL112710 | (3-aminopropyl...)
Affinity DataEC50:  200nMAssay Description:Inhibition of mammalian Gamma-aminobutyric acid type B receptor (potent agonist)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article
PDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593656(CHEMBL5183971)
Affinity DataEC50:  208nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM430534(US10556914, Example 16)
Affinity DataEC50:  222nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

LigandPNGBDBM430538(US10556914, Example 21)
Affinity DataEC50:  229nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032962(CGP38593 | CHEMBL113217 | CHEMBL324917 | CGP70522 ...)
Affinity DataIC50: 280nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM430559(US10556914, Example 49)
Affinity DataEC50:  283nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593657(CHEMBL5187574)
Affinity DataEC50:  294nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593658(CHEMBL5193733)
Affinity DataEC50:  341nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM430531(US10556914, Example 12)
Affinity DataEC50:  347nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032959([3-Amino-2-(4-fluoro-phenyl)-propyl]-phosphinic ac...)
Affinity DataIC50: 360nMAssay Description:Inhibition of [3H]baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM430555(US10556914, Example 45)
Affinity DataEC50:  376nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

LigandPNGBDBM430535(US10556914, Example 18)
Affinity DataEC50:  389nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593652(CHEMBL5188066)
Affinity DataEC50:  419nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM430602(US10556914, Example 103)
Affinity DataEC50:  439nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593649(CHEMBL5202253)
Affinity DataEC50:  444nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
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