Compile Data Set for Download or QSAR
Report error Found 6378 of affinity data for UniProtKB/TrEMBL: P18031
LigandPNGBDBM50061067(8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-...)
Affinity DataIC50: 0.100nMAssay Description:Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

LigandPNGBDBM50110681(Calyculin-A | CHEMBL430266)
Affinity DataIC50: 0.300nMAssay Description:Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

LigandPNGBDBM13467((2R)-2-{[(1S)-1-carbamoyl-2-{4-[difluoro(phosphono...)
Affinity DataIC50: 0.400nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
LigandPNGBDBM50061066((5R,6S,9S,12S,13S,16R)-2-Eth-(Z)-ylidene-9-(3-guan...)
Affinity DataIC50: 0.420nMAssay Description:Observed inhibition activity against protein phosphatase 1 (PP1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50110681(Calyculin-A | CHEMBL430266)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory concentration against Protein phosphatase 1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50649516(CHEMBL5619806)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50366883(TAUTOMYCIN)
Affinity DataIC50: 0.670nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50219599(5-(3-{[1-(benzylsulfonyl)piperidin-4-yl]amino}phen...)
Affinity DataKi:  0.680nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM736420(US20250134882, Example 4)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of human PTP1BMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM13997(5-{3-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy...)
Affinity DataKi:  0.920nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50580002(CHEMBL5084380)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50580003(CHEMBL5080612)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50580005(CHEMBL5093253)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50579994(CHEMBL5070507)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50219588(4-bromo-3-(carboxymethoxy)-5-(3-{[1-({2-[(methylsu...)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50579995(CHEMBL5085502)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50579996(CHEMBL5092308)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50579997(CHEMBL5085615)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50212842(Motuporin)
Affinity DataIC50: 1nMAssay Description:Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

LigandPNGBDBM50579999(CHEMBL5075269)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50580000(CHEMBL5076419)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50110676(okadaic acid | CHEMBL280487)
Affinity DataIC50: 1.20nMAssay Description:Observed inhibition activity against protein phosphatase 1 (PP1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50061067(8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-...)
Affinity DataIC50: 1.20nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50110681(Calyculin-A | CHEMBL430266)
Affinity DataIC50: 1.20nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50611797(CHEMBL5270520)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human GST-tagged PTP1B expressed in Escherichia coli using pNPP as substrate by spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50500145(CHEMBL1235987)
Affinity DataKi:  1.40nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50061069(Calyculin C | CHEMBL384277)
Affinity DataIC50: 1.5nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
LigandPNGBDBM13469(({4-[(2S)-2-carbamoyl-2-[(2S)-2-(1-{4-[difluoro(ph...)
Affinity DataIC50: 1.70nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
LigandPNGBDBM13469(({4-[(2S)-2-carbamoyl-2-[(2S)-2-(1-{4-[difluoro(ph...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human PTP1B catalytic domain expressed in Escherichia coli assessed as pNPP hydrolysis measured every 30 secs for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed
LigandPNGBDBM50202437(CHEMBL502013)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50219577(5-[3-({1-[(2-aminobenzyl)sulfonyl]piperidin-4-yl}a...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50069691(Xanthoangelol | Xanthoangerol)
Affinity DataIC50: 2nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP substrate measured after 3 mins by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50219584(5-{3-[(1-{[2-(acetylamino)benzyl]sulfonyl}piperidi...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50610516(CHEMBL5287377)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM13996(4-amino-5-{3-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50131550((S)-4-((S)-1-amino-3-(4-(difluoro(phosphono)methyl...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50131550((S)-4-((S)-1-amino-3-(4-(difluoro(phosphono)methyl...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50131550((S)-4-((S)-1-amino-3-(4-(difluoro(phosphono)methyl...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50131550((S)-4-((S)-1-amino-3-(4-(difluoro(phosphono)methyl...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of recombinant GST-tagged PTP1B (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP as substrate measured after 2 to 3 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
LigandPNGBDBM50379185(CHEMBL1232859)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) cells using p-nitrophenyl phosphate as substrate after 2 to 3 mins by spectrophotometric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50131550((S)-4-((S)-1-amino-3-(4-(difluoro(phosphono)methyl...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of recombinant PTP1B (1 to 321 residues) (unknown origin) expressed in Escherichia coli using p-nitrophenyl phosphate as substrate by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
LigandPNGBDBM50131550((S)-4-((S)-1-amino-3-(4-(difluoro(phosphono)methyl...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
LigandPNGBDBM50131550((S)-4-((S)-1-amino-3-(4-(difluoro(phosphono)methyl...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2018
Entry Details Article
PubMed
LigandPNGBDBM50131550((S)-4-((S)-1-amino-3-(4-(difluoro(phosphono)methyl...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PTP1B expressed in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50612100(CHEMBL5279725)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50131550((S)-4-((S)-1-amino-3-(4-(difluoro(phosphono)methyl...)
Affinity DataKi:  2.40nMAssay Description:Inhibitory activity against protein-tyrosine phosphatase 1B (PTP 1B) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50131550((S)-4-((S)-1-amino-3-(4-(difluoro(phosphono)methyl...)
Affinity DataKi:  2.40nMAssay Description:Inhibitory activity against Protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM723316(US20250059220, Compound 428)
Affinity DataIC50: 2.5nMAssay Description:Test compounds were dissolved in DMSO, and 10-point serial 3-fold dilution series in DMSO were prepared in Echo Qualified 384-well Polypropylene Micr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

LigandPNGBDBM723332(US20250059220, Compound 444)
Affinity DataIC50: 2.5nMAssay Description:Test compounds were dissolved in DMSO, and 10-point serial 3-fold dilution series in DMSO were prepared in Echo Qualified 384-well Polypropylene Micr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

LigandPNGBDBM723348(US20250059220, Compound 460)
Affinity DataIC50: 2.5nMAssay Description:Test compounds were dissolved in DMSO, and 10-point serial 3-fold dilution series in DMSO were prepared in Echo Qualified 384-well Polypropylene Micr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

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