Compile Data Set for Download or QSAR
Report error Found 10 of affinity data for UniProtKB/TrEMBL: P29074
TargetTyrosine-protein phosphatase non-receptor type 4(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50531902BDBM50531902(CHEMBL4569405)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MEG1 catalytic domain (637 to 926 residues) expressed in Escherichia coli using p-nitrophenol a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 124261BDBM124261(2-((5-Bromo-2-oxybenzylidene)amino)benzoato-diaqua...)
Affinity DataIC50: 600nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 124260BDBM124260(2-((5-Bromo-2-oxybenzylidene)amino)benzoato-diaqua...)
Affinity DataIC50: 970nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 124263BDBM124263(Bis(4-bromo-2-((phenylimino)methyl)phenolate)-oxov...)
Affinity DataIC50: 2.90E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 124264BDBM124264(Bis(4-nitro-2-((phenylimino)methyl)phenolate)-oxov...)
Affinity DataIC50: 3.20E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 124262BDBM124262(Bis(4-chloro-2-((phenylimino)methyl)phenolate)-oxo...)
Affinity DataIC50: 3.60E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50531901BDBM50531901(CHEMBL4540813)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MEG1 catalytic domain (637 to 926 residues) expressed in Escherichia coli using p-nitrophenol a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 231167BDBM231167(US9340574, 7)
Affinity DataIC50: 1.00E+4nMpH: 7.0Assay Description:PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in 3,3-dimethylglutarate buffer (50 mM 3,3-dimethylglutarate, pH 7.0, 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 4(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50531903BDBM50531903(CHEMBL4530344)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MEG1 catalytic domain (637 to 926 residues) expressed in Escherichia coli using p-nitrophenol a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Human)
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50107739BDBM50107739([(4-{4-[4-(Difluoro-phosphono-methyl)-benzyloxy]-p...)
Affinity DataIC50: 1.46E+5nMAssay Description:Inhibitory activity against Protein tyrosine phosphatase PTPmeg-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed