Compile Data Set for Download or QSAR
Report error Found 1294 of affinity data for UniProtKB/TrEMBL: P32246
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50: 0.0810nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174708(N-(2-(3-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpi...)
Affinity DataIC50: 0.100nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50508174(CHEMBL4464625)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50508208(CHEMBL4457209)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50508174(CHEMBL4464625)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50508182(CHEMBL4475581)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50430275(CHEMBL2332933)
Affinity DataIC50: 0.360nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50430274(CHEMBL2332935)
Affinity DataIC50: 0.360nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50430274(CHEMBL2332935)
Affinity DataIC50: 0.360nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174703((R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: 0.400nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM113726(US8633226, 850)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/moleT: 2°CAssay Description:For radioligand competition studies, a final concentration of 1x105 THP-1 monocytic leukemia cells are combined with 100 μg of LS WGA PS beads (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
Go to US Patent

TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50430280(CHEMBL2332936)
Affinity DataIC50: 0.520nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50430280(CHEMBL2332936)
Affinity DataIC50: 0.520nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50445002(CHEMBL3099947)
Affinity DataIC50: 0.630nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50430286(CHEMBL2332931)
Affinity DataIC50: 0.640nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM102335(US8536198, 106)
Affinity DataIC50: 0.700nMAssay Description:CCR1 ligand binding using scintillation proximity assay (SPA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2013
Entry Details
Go to US Patent

TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50436284(CHEMBL2398747 | US8633226, 460)
Affinity DataKi:  0.700nM ΔG°:  -52.3kJ/moleT: 2°CAssay Description:For radioligand competition studies, a final concentration of 1x105 THP-1 monocytic leukemia cells are combined with 100 μg of LS WGA PS beads (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
Go to US Patent

TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)
Affinity DataIC50: 0.730nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50430285(CHEMBL2332940)
Affinity DataIC50: 0.790nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50518185(CHEMBL4571977)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50436256(CHEMBL2398726)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity to human CCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL5/RANTES-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50436283(CHEMBL2398729)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity to human CCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50445004(CHEMBL3099945)
Affinity DataIC50: 0.890nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50451624(CHEMBL331897)
Affinity DataIC50: 0.900nMAssay Description:Binding affinity towards C-C chemokine receptor type 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098643(1-((E)-1-Cyclooct-1-enyl)methyl-4-[(2,7-dichloro-9...)
Affinity DataIC50: 0.900nMAssay Description:Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)
Affinity DataIC50: 0.900nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174707((R)-1-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: 0.900nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50430284(CHEMBL2332930)
Affinity DataIC50: 0.900nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50435690(CHEMBL2391803)
Affinity DataIC50: 0.920nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50430283(CHEMBL2332932)
Affinity DataIC50: 0.960nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50430282(CHEMBL2332934)
Affinity DataIC50: 0.960nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataKi:  1nMAssay Description:Binding affinity to CCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM102327(US8536198, 80)
Affinity DataIC50: 1nMAssay Description:CCR1 ligand binding using scintillation proximity assay (SPA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2013
Entry Details
Go to US Patent

TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataKd:  1nMAssay Description:Binding affinity to human CCR1 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144428(Quinoxaline-2-carboxylic acid ((1S,2S)-1-benzyl-7-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056504(CHEMBL3334824)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174711(N-(2-(3-((2S,5R)-4-(4-fluorobenzyl)-2,5-dimethylpi...)
Affinity DataIC50: 1nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: 1nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174709(N-(2-(3-(3-(4-fluorobenzyl)-3,8-diaza-bicyclo[3.2....)
Affinity DataIC50: 1nMAssay Description:Antagonistic activity at rat CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50436260(CHEMBL2398717)
Affinity DataIC50: 1nMAssay Description:Binding affinity to human CCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50436256(CHEMBL2398726)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CCR1 assessed as inhibition of RANTES-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50508174(CHEMBL4464625)
Affinity DataIC50: 1nMAssay Description:Inhibition of MIP1alpha-stimulated CCR1 internalization in human whole blood preincubated for 30 mins followed by MIP1alpha-stimulation and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056498(CHEMBL3334818)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50435689(CHEMBL2391810)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50436288(CHEMBL2398728)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50451624(CHEMBL331897)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human CCR1 transfected in CHO cells incubated for 1 hr in presence of 125I-chemokine by radioactivity based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50508210(CHEMBL4518015)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50436282(CHEMBL2398769)
Affinity DataIC50: 1.20nMAssay Description:Binding affinity to human CCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
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