Compile Data Set for Download or QSAR
Report error Found 243 for UniProtKB: P60900
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataEC50:  1.48E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataEC50:  7.80E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50002338(10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsul...)
Affinity DataEC50:  1.20E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM79211(METHIXENE | MLS002153842 | cid_71177 | Metixene hy...)
Affinity DataEC50:  1.19E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataEC50:  1.24E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataEC50:  9.90E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65507(CPZ analog, 1)
Affinity DataEC50: >2.50E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65508(CPZ analog, 2)
Affinity DataEC50:  6.30E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65509(CPZ analog, 3)
Affinity DataEC50: >2.50E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65510(CPZ analog, 4)
Affinity DataEC50: >2.50E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65511(CPZ analog, 5)
Affinity DataEC50:  8.90E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65512(CPZ analog, 6)
Affinity DataEC50: >2.50E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65513(CPZ analog, 7)
Affinity DataEC50:  6.40E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65514(CPZ analog, 8)
Affinity DataEC50:  1.56E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50518761(CHEMBL4573271)
Affinity DataEC50:  2.40E+4nMAssay Description:Stimulation of human 20S proteasome using 11 amino acid FRET peptide as substrate measured every 2 mins over 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50518762(CHEMBL4561568)
Affinity DataEC50:  3.50E+4nMAssay Description:Stimulation of human 20S proteasome using 11 amino acid FRET peptide as substrate measured every 2 mins over 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50054471(cid_6604822 | (5Z,8Z)-Icosa-5,8,11,14-tetraenoic a...)
Affinity DataEC50:  2.80E+4nMAssay Description:Stimulation of human 20S proteasome using 11 amino acid FRET peptide as substrate measured every 2 mins over 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  41nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  3.60E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50476098(Cinnabaramide G)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human 20S proteasomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50234982(CHEMBL4102324)
Affinity DataIC50: 0.920nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50476095(CINNABARAMIDE A)
Affinity DataIC50: 1nMAssay Description:Inhibition of human 20S proteasomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50398608(MARIZOMIB)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of 20S proteasome (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
LigandPNGBDBM50531806(CHEMBL4460323)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50031442(Alpha-ketocarbonyl derivative | 1N-[4-amino(nitroi...)
Affinity DataIC50: 2nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
LigandPNGBDBM50531814(CHEMBL4517600)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50514365(CHEMBL4587036)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50531815(CHEMBL4444107)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50603962(CHEMBL5197285)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50531807(CHEMBL4541038)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50531812(CHEMBL4547405)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50603940(CHEMBL5171225)
Affinity DataIC50: 4nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50514367(CHEMBL4581126)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50531813(CHEMBL4542373)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50531826(CHEMBL4558648)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50531808(CHEMBL4467618)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM588478(US11542283, Compound IV-9 | (R)-N-(2,5-dichloroben...)
Affinity DataIC50: 4.86nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

LigandPNGBDBM50603963(CHEMBL5186240)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50516758(CHEMBL4444471 | US11542283, Compound V-9A)
Affinity DataIC50: 5.69nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

LigandPNGBDBM50031440(Alpha-ketocarbonyl derivative | 1N-[4-amino(nitroi...)
Affinity DataIC50: 6nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
LigandPNGBDBM50476097(Cinnabaramide F)
Affinity DataIC50: 6nMAssay Description:Inhibition of human 20S proteasomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50514366(CHEMBL4447701)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50531825(CHEMBL4435814)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50531816(CHEMBL4436430)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM588482(US11542283, Compound V-9B | (R)-N-(2,5-dichloroben...)
Affinity DataIC50: 6.60nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50469762(CHEMBL432281)
Affinity DataIC50: 7nMAssay Description:Tested in vitro for inhibition of chymotrypsin like activity of purified human 20S proteasomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2020
Entry Details Article
PubMed
LigandPNGBDBM50475041(CHEMBL181131 | TP-104)
Affinity DataIC50: 7nMAssay Description:Inhibitory concentration to inhibit chymotrypsin-like activity of 20S proteasome prepared from human leukemia HL-60 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50277889(CHEMBL451887 | CARFILZOMIB)
Affinity DataIC50: 7nMAssay Description:Inhibition of human 20S proteasome chymotrypsin-like activity in human RPMI-8226 cells using Suc-LLVY-AMC as fluorogenic substrate incubated for 3 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50603953(CHEMBL5202627)
Affinity DataIC50: 7nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
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