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TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50449890(CHEMBL4161876)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142519(N-[2-(3,4,5-triihydroxy-benzoylamino)-phenyl]-3,4,...)
Affinity DataIC50: 9nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase II by detecting the conversion of supercoiled pBR322 DNA to its relaxed for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50449891(CHEMBL4174756)
Affinity DataIC50: 13nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470378(CHEMBL108283)
Affinity DataIC50: 20nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50410828(CHEMBL5266387)
Affinity DataIC50: 26nMAssay Description:Inhibition of human DNA topoisomerase 2-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM21690(Ciprinol | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperaz...)
Affinity DataEC50:  30nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50520631(Ametantrone)
Affinity DataIC50: 30nMAssay Description:Poison activity at recombinant human topoisomerase 2beta using pBR322 plasmid as substrate after 30 mins by ethidium bromide staining based agarose g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50449889(CHEMBL4160802)
Affinity DataIC50: 32nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470365(CHEMBL326664)
Affinity DataIC50: 45nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470374(CHEMBL322325)
Affinity DataIC50: 54nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470371(CHEMBL325543)
Affinity DataIC50: 63nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50449888(CHEMBL4172196)
Affinity DataIC50: 81nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50213799(CHEMBL440642)
Affinity DataEC50:  96nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50213803(CHEMBL428339)
Affinity DataEC50:  98nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50449887(CHEMBL4169404)
Affinity DataIC50: 110nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470361(CHEMBL108404)
Affinity DataIC50: 116nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50547613(CHEMBL4751362)
Affinity DataIC50: 130nMAssay Description:Inhibition of Topoisomerase II beta (unknown origin) relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142517(N-[4-(3,4,5-triihydroxy-benzoylamino)-phenyl]-3,4,...)
Affinity DataIC50: 150nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase II by detecting the conversion of supercoiled pBR322 DNA to its relaxed for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50473498(Ro-616653 | CHEMBL157831)
Affinity DataIC50: 157nMAssay Description:Antibacterial activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50473498(Ro-616653 | CHEMBL157831)
Affinity DataIC50: 157nMAssay Description:Antibacterial activity against Micrococcus luteus DNA gyrase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50213805(CHEMBL7877)
Affinity DataEC50:  160nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50213812(CHEMBL269139)
Affinity DataEC50:  160nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142507(N-[3-(3,4,5-triihydroxy-benzoylamino)-phenyl]-3,4,...)
Affinity DataIC50: 220nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase II by detecting the conversion of supercoiled pBR322 DNA to its relaxed for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470369(CHEMBL325588)
Affinity DataIC50: 226nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50525581(CHEMBL4469453)
Affinity DataIC50: 230nMAssay Description:Inhibition of DNA topoisomerase 2 in human MCF7 cells incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50471898(CHEMBL135778)
Affinity DataIC50: 240nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50473499(BAY-507950 | CHEMBL156813)
Affinity DataIC50: 326nMAssay Description:Antibacterial activity against Micrococcus luteus DNA gyrase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50214091(CHEMBL27233)
Affinity DataEC50:  330nMAssay Description:In vitro evaluation for inhibitor of human topoisomerase II from HeLa cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50213795(CHEMBL268458)
Affinity DataEC50:  330nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50214091(CHEMBL27233)
Affinity DataEC50:  330nMAssay Description:Inhibition of topoisomerase II purified from HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2018
Entry Details

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50213794(CHEMBL7690)
Affinity DataEC50:  360nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50471897(CHEMBL137098)
Affinity DataIC50: 420nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50525582(CHEMBL4470431)
Affinity DataIC50: 440nMAssay Description:Inhibition of DNA topoisomerase 2 in human MCF7 cells incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50471907(CHEMBL337526)
Affinity DataIC50: 440nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50229974(CHEMBL178077)
Affinity DataIC50: 452nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50008935(CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...)
Affinity DataIC50: 480nMAssay Description:Inhibition of DNA topoisomerase 2 in human MCF7 cells incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50473499(BAY-507950 | CHEMBL156813)
Affinity DataIC50: 489nMAssay Description:Antibacterial activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50471900(CHEMBL335700)
Affinity DataIC50: 490nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470684(CHEMBL173975)
Affinity DataIC50: 500nMAssay Description:Inhibitory activity for 50% on topoisomerase II isolated from Giardia lambliaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50286492(2-(4-Amino-cyclohexyl)-5-cyclopropyl-7-(2,6-dimeth...)
Affinity DataEC50:  500nMAssay Description:Compound was tested for topoisomerase II inhibition in purified HeLa cells by SDS/K+ precipitation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50471783(CHEMBL121666)
Affinity DataEC50:  500nMAssay Description:In vitro evaluation for inhibitor of human topoisomerase II from HeLa cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470690(CHEMBL367883)
Affinity DataIC50: 500nMAssay Description:Inhibitory activity for 50% on topoisomerase II isolated from Giardia lambliaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50471895(CHEMBL101299 | A-62176)
Affinity DataIC50: 510nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50471905(CHEMBL334497)
Affinity DataIC50: 550nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50623278(CHEMBL5408150)
Affinity DataIC50: 550nMAssay Description:Inhibition of human DNA topoisomerase 2 beta assessed as relaxation of supercoiled plasmid pBR322 DNA incubated for 30 mins by ethidium bromide stain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50213996(CHEMBL30104)
Affinity DataEC50:  550nMAssay Description:In vitro evaluation for inhibitor of human topoisomerase II from HeLa cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50213996(CHEMBL30104)
Affinity DataEC50:  550nMAssay Description:Inhibition of topoisomerase II purified from HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2018
Entry Details

TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50458474(CHEMBL4213218)
Affinity DataIC50: 580nMAssay Description:Inhibition of human topoisomerase-2B after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM21690(Ciprinol | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperaz...)
Affinity DataIC50: 603nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
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