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Found 136 for UniProtKB: Q9NXG6
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511484(US11059789, Example 33 | US11691950, Example 33)
Affinity DataIC50:  4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511485(US11059789, Example 27 | US11691950, Example 27)
Affinity DataIC50:  6nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511480(US11059789, Example 40 | US11691950, Example 40)
Affinity DataIC50:  11nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511483(US11059789, Example 66 | US11691950, Example 66)
Affinity DataIC50:  15nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511482(US11059789, Example 83 | US11691950, Example 83)
Affinity DataIC50:  25nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM105221(US8580778, 21)
Affinity DataIC50:  70nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM105220(US8580778, 20)
Affinity DataIC50:  90nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM105219(US8580778, 17)
Affinity DataIC50:  130nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM105224(US8580778, 29)
Affinity DataIC50:  170nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM3527(US8524699, 18)
Affinity DataIC50:  180nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM105222(US8580778, 25)
Affinity DataIC50:  180nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50042876(CHEMBL332005 | [2,2']Bipyridinyl-5,5'-dicarboxylic...)
Affinity DataIC50:  185nMAssay Description:Inhibition of prolyl 4-hydroxylase by chromatographic determination of [14C]-succinic acid on ion-exchange minicolumnaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50042876(CHEMBL332005 | [2,2']Bipyridinyl-5,5'-dicarboxylic...)
Affinity DataIC50:  190nMAssay Description:Inhibition of prolyl 4-hydroxylase by chromatographic determination of [14C]-succinic acid on ion-exchange minicolumnaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM109268(US8609698, 10)
Affinity DataIC50:  260nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50042873(5'-(4-Ethoxy-phenylcarbamoyl)-[2,2']bipyridinyl-5-...)
Affinity DataIC50:  320nMAssay Description:Inhibition of prolyl 4-hydroxylase by chromatographic determination of [14C]-succinic acid on ion-exchange minicolumnaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM105223(US8580778, 26)
Affinity DataIC50:  380nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM3543(US8524699, 16)
Affinity DataIC50:  480nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM105217(US8580778, 5)
Affinity DataIC50:  540nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM3555(US8524699, 3)
Affinity DataIC50:  700nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM105218(US8580778, 9)
Affinity DataIC50:  760nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM105216(US8580778, 2)
Affinity DataIC50:  880nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM3591(US8524699, 7)
Affinity DataIC50:  880nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM3623(US8524699, 28)
Affinity DataIC50:  890nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM109271(US8609698, 65)
Affinity DataIC50:  900nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM109269(US8609698, 18)
Affinity DataIC50:  910nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM3629(US8524699, 46)
Affinity DataIC50:  930nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50368560(CHEMBL1744254)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of prolyl 4-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50000409(5-Benzenesulfonylaminocarbonyl-pyridine-2-carboxyl...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of prolyl 4-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM3643(US8524699, 44)
Affinity DataIC50:  1.12E+3nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50368564(CHEMBL1203805)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of prolyl 4-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM109272(US8609698, 80)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM3644(US8524699, 55)
Affinity DataIC50:  1.70E+3nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50368565(CHEMBL1203806)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of prolyl 4-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50368562(CHEMBL1744252)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of prolyl 4-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50368561(CHEMBL1744251)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of prolyl 4-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM3698(US8524699, 22)
Affinity DataIC50:  2.70E+3nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM3723(US8524699, 6)
Affinity DataIC50:  2.80E+3nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50000400(5-Phenylmethanesulfonylaminocarbonyl-pyridine-2-ca...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of prolyl 4-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM109270(US8609698, 22)
Affinity DataIC50:  3.24E+3nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM109273(US8609698, 89)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM3734(US8524699, 26)
Affinity DataIC50:  4.00E+3nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50000438(5-(4-Dimethylamino-phenylcarbamoyl)-pyridine-2-car...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of prolyl 4-hydroxylase activity by an indirect assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50000416(5-(Naphthalene-1-sulfonylaminocarbonyl)-pyridine-2...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of prolyl 4-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50000430(5-(4-Ethoxy-phenylcarbamoyl)-pyridine-2-carboxylic...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of prolyl 4-hydroxylase activity by an indirect assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50042872(3-phenylsulfonamidocarbonyl-6-(5-phenylsulfonamido...)
Affinity DataIC50:  5.04E+3nMAssay Description:Inhibition of prolyl 4-hydroxylase by chromatographic determination of [14C]-succinic acid on ion-exchange minicolumnaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM26114(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Affinity DataIC50:  5.18E+3nMAssay Description:Inhibition of prolyl 4-hydroxylase by chromatographic determination of [14C]-succinic acid on ion-exchange minicolumnaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM109267(US8609698, 8)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM26114(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of prolyl 4-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM26114(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of prolyl 4-hydroxylase activity by an indirect assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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