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TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550633(CHEMBL4763515)
Affinity DataIC50: 0.200nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50108997(CGP-71872 | CHEMBL1628548)
Affinity DataKd:  1nMAssay Description:Binding affinity to GABA-B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550634(CHEMBL4791366)
Affinity DataIC50: 1.20nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24184((3-aminopropyl)phosphinic acid | CHEMBL112203 | CG...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550631(CHEMBL4756657)
Affinity DataIC50: 2.40nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1(Human)
Broad Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM50435128(CHEMBL2391908)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550632(CHEMBL4787614)
Affinity DataIC50: 4.90nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1(Human)
Broad Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM50435128(CHEMBL2391908)
Affinity DataIC50: 6.40nMAssay Description:Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24185(CGP35024 | 3-Apmpa | CHEMBL112710 | (3-aminopropyl...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50108998(CHEMBL3600560)
Affinity DataEC50:  8.60nMAssay Description:Agonist activity at human recombinant GABA-B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50570461(CHEMBL4847170)
Affinity DataIC50: 13nMAssay Description:Agonist activity at human GABAB expressed in HEK293T cells co-transfected with human CaV2.2 channel assessed as inhibition of CaV2.2-mediated Ba2+ pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032964(4-Amino-3-(4-chloro-phenyl)-butyric acid | (R)-4-A...)
Affinity DataIC50: 15nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24186(3-aminopropylphosphinic derivative, (S)-3 | CHEMBL...)
Affinity DataIC50: 18nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550638(CHEMBL4762233)
Affinity DataIC50: 19nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550636(CHEMBL4745449)
Affinity DataIC50: 19nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50570462(CHEMBL4856595)
Affinity DataIC50: 21nMAssay Description:Agonist activity at human GABAB expressed in HEK293T cells co-transfected with human CaV2.2 channel assessed as inhibition of CaV2.2-mediated Ba2+ pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550639(CHEMBL4740566)
Affinity DataIC50: 23nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataIC50: 25nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24189(CHEMBL113304 | [(2S)-3-amino-2-hydroxypropyl](meth...)
Affinity DataIC50: 29nMAssay Description:Inhibition of [3H]CGP-27492 binding to cat Gamma-aminobutyric acid type B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24182(4-amino-3-(4-chlorophenyl)butanoic acid | CHEMBL70...)
Affinity DataIC50: 35nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032958([3-Amino-2-(4-chloro-phenyl)-propyl]-phosphinic ac...)
Affinity DataIC50: 39nMAssay Description:Inhibition of [3H]baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593659(CHEMBL5207265)
Affinity DataEC50:  64nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1(Human)
Broad Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM86283(N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-py...)
Affinity DataEC50:  79nMAssay Description:Positive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593660(CHEMBL5170235)
Affinity DataEC50:  90nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593653(CHEMBL5185974)
Affinity DataEC50:  97nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593654(CHEMBL5204436)
Affinity DataEC50:  142nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032971(CGP-35582 | (3-Amino-1-methyl-propyl)-methyl-phosp...)
Affinity DataIC50: 166nMAssay Description:Inhibition of [3H]CGP-27492 binding to cat Gamma-aminobutyric acid type B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593650(CHEMBL5169533)
Affinity DataEC50:  199nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24185(CGP35024 | 3-Apmpa | CHEMBL112710 | (3-aminopropyl...)
Affinity DataEC50:  200nMAssay Description:Inhibition of mammalian Gamma-aminobutyric acid type B receptor (potent agonist)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article
PDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593656(CHEMBL5183971)
Affinity DataEC50:  208nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032962(CGP38593 | CHEMBL113217 | CHEMBL324917 | CGP70522 ...)
Affinity DataIC50: 280nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593657(CHEMBL5187574)
Affinity DataEC50:  294nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593658(CHEMBL5193733)
Affinity DataEC50:  341nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032959([3-Amino-2-(4-fluoro-phenyl)-propyl]-phosphinic ac...)
Affinity DataIC50: 360nMAssay Description:Inhibition of [3H]baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593652(CHEMBL5188066)
Affinity DataEC50:  419nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593649(CHEMBL5202253)
Affinity DataEC50:  444nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593651(CHEMBL5186902)
Affinity DataEC50:  496nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032970((3-Amino-butyl)-phosphinic acid | CHEMBL113907)
Affinity DataIC50: 500nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataEC50:  530nMAssay Description:Agonist activity at human GABA-B B1/B2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 3 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50007118(CHEMBL87482 | 4-Amino-3-(5-chloro-thiophen-2-yl)-b...)
Affinity DataIC50: 610nMAssay Description:Binding affinity to GABA-B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593655(CHEMBL5209256)
Affinity DataEC50:  637nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM86283(N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-py...)
Affinity DataEC50:  741nMAssay Description:Activity at GABAB 1b/2 receptor expressed in CHO-K1 cells assessed as effect on glutamate-induced [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593661(CHEMBL2346820)
Affinity DataEC50:  764nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50593648(CHEMBL5209395)
Affinity DataEC50:  771nMAssay Description:Positive allosteric modulation of GABA-B receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032975((3-Amino-2-methyl-propyl)-phosphinic acid | CHEMBL...)
Affinity DataIC50: 780nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50477169(CHEMBL393066)
Affinity DataEC50:  871nMAssay Description:Activity at GABAB 1b/2 receptor expressed in CHO-K1 cells assessed as effect on glutamate-induced [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032977((3-Amino-2-phenyl-propyl)-phosphinic acid | CHEMBL...)
Affinity DataIC50: 880nMAssay Description:Inhibition of [3H]baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032967((3-Amino-1-methyl-propyl)-phosphinic acid | CHEMBL...)
Affinity DataIC50: 920nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032964(4-Amino-3-(4-chloro-phenyl)-butyric acid | (R)-4-A...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human GABA-B B1/B2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 3 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550637(CHEMBL4780501)
Affinity DataIC50: 1.00E+3nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
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