PMID

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Article Title

Organization

Crystal structures, binding interactions, and ADME evaluation of brain penetrant N-substituted indazole-5-carboxamides as subnanomolar, selective monoamine oxidase B and dual MAO-A/B inhibitors.

Ntz Lab

Enzyme-activated irreversible inhibitors of monoamine oxidase: phenylallylamine structure-activity relationships.

TBA

Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes.

TBA

Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson's disease.

China Pharmaceutical University

2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase.

North-West University

3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1.

Baylor College Of Medicine

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.

Universit£

a-Ketoamino acid ester derivatives as promising MAO inhibitors.

King Saud University

Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease.

A* Star

N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.

Laboratorio De Quimica Medica (Iqog, Csic)

Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.

Dart Neuroscience

Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency.

University Of Bonn

In silico design of novel 2H-chromen-2-one derivatives as potent and selective MAO-B inhibitors.

Universit£

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.

Okayama University

Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines.

Neurosearch Sweden

Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.

Universit£

Structural insights into monoamine oxidase inhibitory potency and selectivity of 7-substituted coumarins from ligand- and target-based approaches.

Universit£

Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.

Universit£

Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs.

Universit£

Systematic in vivo screening of a series of 1-propyl-4-arylpiperidines against dopaminergic and serotonergic properties in rat brain: a scaffold-jumping approach.

Neurosearch Sweden

Synthesis and evaluation of a set of para-substituted 4-phenylpiperidines and 4-phenylpiperazines as monoamine oxidase (MAO) inhibitors.

Neurosearch Sweden

Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs.

TBA

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.

Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)

Synthesis and inhibitory effect of piperine derivates on monoamine oxidase.

General Hospital Of Pla

2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.

University Of Chile

Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.

University Of Chile

A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics.

Hacettepe University

Alkylamino derivatives of 4-aminomethylpyridine as inhibitors of copper-containing amine oxidases.

Universit£

Selective inhibitors of monoamine oxidase. 4. SAR of tricyclic N-methylcarboxamides and congeners binding at the tricyclics' hydrophilic binding site.

Wellcome Research Laboratories

5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type B inhibitors.

Universit£

Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors.

University Of Saskatchewan

(+/-)-4-Aryl-4,5-dihydro-3H-1,3-benzodiazepines. 1. Synthesis and evaluation of (+/-)-4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine and analogues as potential antidepressant agents.

TBA

 

Synthesis of coumarins as subtype-selective inhibitors of monoamine oxidase

TBA

Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.

Universitat Aut£Noma De Barcelona

Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation.

Birla Institute Of Technology

Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.

Nanjing University

Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.

University Of Cambridge

Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and docking studies.

Institute Of Technology

Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors.

Hacettepe University

Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B

Universita Degli Studi Di Bari

New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.

Hacettepe University

Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors.

Universidade Federal De Santa Maria

Pyrazoline-based mycobactin analogues as MAO-inhibitors.

Institute Of Technology

Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.

University Of Bari

Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies.

University Of Santiago De Chile

3-[5-(4,5-dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor.

Università

Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core.

FacultéS Universitaires N.D. De La Paix

Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors.

University Of Alexandria

Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors.

Sapienza University Of Rome

Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling.

Universidad De Chile

Novel pyridazino[4,3-b]indoles with dual inhibitory activity against Mycobacterium tuberculosis and monoamine oxidase.

Russian Academy Of Sciences

Synthesis of N-propargylphenelzine and analogues as neuroprotective agents.

Cv Technologies

Bioactive Dimeric Acylphloroglucinols from the Mexican Fern Elaphoglossum paleaceum.

Universidad Aut£Noma Del Estado De Morelos

Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens.

Sunchon National University

Molecular determinants of MAO selectivity in a series of indolylmethylamine derivatives: biological activities, 3D-QSAR/CoMFA analysis, and computational simulation of ligand recognition.

Universitat AutòNoma De Barcelona

Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.

Sunchon National University

(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.

Ntz Lab

Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor.

Rti International

Multi-target design strategies for the improved treatment of Alzheimer's disease.

China Pharmaceutical University

Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships.

Université

Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).

Csir-Central Drug Research Institute

Selective inhibitors of monoamine oxidase (MAO). 5. 1-Substituted phenoxathiin inhibitors containing no nitrogen that inhibit MAO A by binding it to a hydrophobic site.

The Wellcome Research Laboratories

Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms.

China Pharmaceutical University

Selective inhibitors of monoamine oxidase. 3. Structure-activity relationship of tricyclics bearing imidazoline, oxadiazole, or tetrazole groups.

Wellcome Research Laboratories

Fine molecular tuning at position 4 of 2H-chromen-2-one derivatives in the search of potent and selective monoamine oxidase B inhibitors.

Universit£

Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives.

North-West University

Selective inhibitors of monoamine oxidase. 2. Arylamide SAR.

Burroughs Wellcome

Selected furanochalcones as inhibitors of monoamine oxidase.

North-West University

Inhibition of monoamine oxidase by phthalide analogues.

North-West University

Inhibition of monoamine oxidase-B by 5H-indeno[1,2-c]pyridazines: biological activities, quantitative structure-activity relationships (QSARs) and 3D-QSARs.

Université

Selective and potent monoamine oxidase type B inhibitors: 2-substituted 5-aryltetrazole derivatives.

Université

Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.

China Pharmaceutical University

Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-aminoethyl)-2,3-dihydroindoles.

TBA

Design, synthesis and biological evaluation of lazabemide derivatives as inhibitors of monoamine oxidase.

Hainan Normal University

Synthesis, monoamine oxidase inhibition activity and molecular docking studies of novel 4-hydroxy-N'-[benzylidene or 1-phenylethylidene]-2-H/methyl/benzyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides.

Government College University

A selective, reversible, competitive inhibitor of monoamine oxidase A containing no nitrogen, with negligible potentiation of tyramine-induced blood pressure rise.

Burroughs Wellcome

Benzyloxynitrostyrene analogues - A novel class of selective and highly potent inhibitors of monoamine oxidase B.

North-West University

Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist.

Yamanouchi Pharmaceutical

Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase.

Astrazeneca