Compile Data Set for Download or QSAR
maximum 50k data
Found 139 with Last Name = 'manallack' and Initial = 'dt'
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)
Affinity DataKi:  1nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataKi:  10nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataKi:  10nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50027177(Cilostamide)
Affinity DataKi:  20nMAssay Description:Inhibition of human phosphodiesterase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM82087(2-(5-methoxy-1H-indol-3-yl)ethanamine | 5-MT | 5-M...)
Affinity DataKi:  26.9nMAssay Description:Displacement of [3H]GR-113808 from human 5HT4b receptor expressed in COS7 cell membrane by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  29.5nMAssay Description:Displacement of [3H]GR-113808 from human 5HT4b receptor expressed in COS7 cell membrane by scintillation countingMore data for this Ligand-Target Pair
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataKi:  50nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]GR-113808 from human recombinant 5HT4b receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Affinity DataKi:  125nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14363(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Affinity DataKi:  130nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM50414474(CHEMBL550302)
Affinity DataKi:  145nMAssay Description:Displacement of [3H]GR-113808 from human 5HT4b receptor expressed in COS7 cell membrane by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataKi:  150nMAssay Description:Inhibition of human phosphodiesterase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM82087(2-(5-methoxy-1H-indol-3-yl)ethanamine | 5-MT | 5-M...)
Affinity DataKi:  245nMAssay Description:Displacement of [3H]GR-113808 from human recombinant 5HT4b receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14363(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Affinity DataKi:  400nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Affinity DataKi:  400nMAssay Description:Inhibition of human phosphodiesterase 11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Affinity DataKi:  600nMAssay Description:Inhibition of human phosphodiesterase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibitory activity against phosphodiesterase 10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50034908((2R,3S)-3-((R)-6-Amino-purin-9-yl)-nonan-2-ol | (2...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of human phosphodiesterase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of human phosphodiesterase 4More data for this Ligand-Target Pair
LigandPNGBDBM50027176(2-Acetoxy-Benzoic Acid | 3-Isobutyl-Methylxanthine...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human phosphodiesterase 7More data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14363(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of human phosphodiesterase 11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50059033((11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of human phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14363(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Affinity DataKi:  3.50E+4nMAssay Description:Inhibition of human phosphodiesterase 9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human phosphodiesterase 4More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290670(5-Mercapto-5-[(S)-3-methyl-1-((S)-1-methylcarbamoy...)
Affinity DataIC50:  1nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50279106(4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one | ...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Kv1.3 expressed in mouse L929 cells exposed to depolarizing step pulses from -80 mV to +40 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290671((S)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  3nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290675(5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-mercapto...)
Affinity DataIC50:  3nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50100087(5-Phenyl-2-[4-(pyridine-4-carbonyl)-benzenesulfony...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50100087(5-Phenyl-2-[4-(pyridine-4-carbonyl)-benzenesulfony...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50100089(2-(4-Benzoyl-benzenesulfonylmethyl)-5-phenyl-penta...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human phosphodiesterase 2More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290671((S)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  5nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50100089(2-(4-Benzoyl-benzenesulfonylmethyl)-5-phenyl-penta...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290668(2-Mercapto-5-methanesulfonylamino-pentanoic acid [...)
Affinity DataIC50:  6nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50266017(5-(3,5-di-tert-butyl-4-hydroxyphenyl)-3H-1,2-dithi...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as effect on prostaglandin E2 production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290671((S)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  9nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290671((S)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  10nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290670(5-Mercapto-5-[(S)-3-methyl-1-((S)-1-methylcarbamoy...)
Affinity DataIC50:  14nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50100087(5-Phenyl-2-[4-(pyridine-4-carbonyl)-benzenesulfony...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290669((S)-2-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-m...)
Affinity DataIC50:  15nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290667(5-Mercapto-5-[(S)-3-methyl-1-((S)-1-methylcarbamoy...)
Affinity DataIC50:  15nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50100089(2-(4-Benzoyl-benzenesulfonylmethyl)-5-phenyl-penta...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290668(2-Mercapto-5-methanesulfonylamino-pentanoic acid [...)
Affinity DataIC50:  19nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290678((S)-2-(2-Mercapto-3-phenyl-propionylamino)-4-methy...)
Affinity DataIC50:  20nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50358828(CHEMBL1922946)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant PDE4D2 overexpressed in Escherichia coli after 15 mins using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290675(5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-mercapto...)
Affinity DataIC50:  25nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50358830(CHEMBL1923066)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant PDE4D2 overexpressed in Escherichia coli after 15 mins using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human platelet COX1 assessed as effect on prostaglandin E2 production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 139 total ) | Next | Last >>
Jump to: