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Found 3829 Enz. Inhib. hit(s) with Target = 'Sphingosine 1-phosphate receptor 3'
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM22202(S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphat...)
Affinity DataKi:  5.40nM ΔG°:  -43.9kJ/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23165(CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...)
Affinity DataKi:  5.90nM ΔG°:  -43.7kJ/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataKi:  13nM ΔG°:  -41.8kJ/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50198836(CHEMBL389033 | [3-amino-3-(3-octylphenylcarbamoyl)...)
Affinity DataKi:  300nMAssay Description:Displacement of [32P]S1P from human S1P3 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50133425(CHEMBL227371 | CHEMBL422074 | Phosphoric acid mono...)
Affinity DataKi:  300nMAssay Description:Displacement of [32P]S1P from human S1P3 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23164(CHEMBL190006 | FTY720-phosphate, (R)-2 | [(2R)-2-a...)
Affinity DataKi:  586nM ΔG°:  -33.1kJ/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50248369(CHEMBL4076530)
Affinity DataKi:  1.04E+3nMAssay Description:Displacement of [33P]-S1P from S1P3 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by microbeta scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50248368(CHEMBL4085783)
Affinity DataKi:  2.20E+3nMAssay Description:Displacement of [33P]-S1P from S1P3 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by microbeta scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50494302(CHEMBL3086532)
Affinity DataKi:  4.88E+3nMAssay Description:Inhibition of S1P3 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi: >5.63E+3nMAssay Description:Displacement of [33P]-S1P from human S1P3 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranesMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.260nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50249114((S)-2-amino-2-methyl-3-oxo-3-(4-(5-phenylpentyloxy...)
Affinity DataIC50:  0.360nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [32P]S1P from human recombinant S1PR3 incubated for 60 mins by competitive binding assay based scintillation counterMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [32P]S1P from recombinant human S1PR3 expressed in Chem1 cell membranes co-expressing Galpha15 pretreated for 30 mins followed by [32...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.400nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.660nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptorMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50147714(CHEMBL432067 | Phosphoric acid mono-[2-amino-4-(4-...)
Affinity DataIC50:  0.710nMAssay Description:Displacement of [33P]-S1P from human S1P3 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50147714(CHEMBL432067 | Phosphoric acid mono-[2-amino-4-(4-...)
Affinity DataIC50:  0.710nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM101157(US8524917, 130 | US8524917, 165)
Affinity DataIC50:  0.900nMAssay Description:Inhibition assay using sphingosine-1-phosphate receptor 3.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148393(CHEMBL119349 | [3-(10-Phenyl-decylamino)-propyl]-p...)
Affinity DataIC50:  0.910nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148433(CHEMBL333335 | [3-(4-Nonyloxy-benzylamino)-propyl]...)
Affinity DataIC50:  1.10nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148425(CHEMBL119873 | [3-(3-Fluoro-4-octyloxy-benzylamino...)
Affinity DataIC50:  1.20nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM101041(US8524917, 14)
Affinity DataIC50:  1.20nMAssay Description:Inhibition assay using sphingosine-1-phosphate receptor 3.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148401((3-Amino-13-phenyl-tridecyl)-phosphonic acid | CHE...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148394(CHEMBL118860 | [3-(4-Nonyl-benzylamino)-propyl]-ph...)
Affinity DataIC50:  2.70nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50152322(CHEMBL184879 | {2-[5-(4-Nonyl-phenyl)-pyrrolidin-2...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148394(CHEMBL118860 | [3-(4-Nonyl-benzylamino)-propyl]-ph...)
Affinity DataIC50:  2.70nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148407((3-Pentadecylamino-propyl)-phosphonic acid | CHEMB...)
Affinity DataIC50:  2.70nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148418(CHEMBL119256 | [3-(4-Octyl-benzylamino)-propyl]-ph...)
Affinity DataIC50:  2.70nMAssay Description:Displacement of [33P]-S1P from human S1P3 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148394(CHEMBL118860 | [3-(4-Nonyl-benzylamino)-propyl]-ph...)
Affinity DataIC50:  2.70nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50152322(CHEMBL184879 | {2-[5-(4-Nonyl-phenyl)-pyrrolidin-2...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148397((3-Tridecylamino-propyl)-phosphonic acid | CHEMBL1...)
Affinity DataIC50:  2.80nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM101040(US8524917, 13)
Affinity DataIC50:  3nMAssay Description:Inhibition assay using sphingosine-1-phosphate receptor 3.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM101044(US8524917, 17)
Affinity DataIC50:  3nMAssay Description:Inhibition assay using sphingosine-1-phosphate receptor 3.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM101216(US8524917, 189)
Affinity DataIC50:  3nMAssay Description:Inhibition assay using sphingosine-1-phosphate receptor 3.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50499644(CHEMBL3741414)
Affinity DataIC50:  3nMAssay Description:Displacement of [33P]S1P from S1P3 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148394(CHEMBL118860 | [3-(4-Nonyl-benzylamino)-propyl]-ph...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50277185((S)-2-amino-3-(2-fluoro-4-(octyloxy)phenylamino)-2...)
Affinity DataIC50:  3.60nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148403((3-Tetradecylamino-propyl)-phosphonic acid | 3-(te...)
Affinity DataIC50:  3.60nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148403((3-Tetradecylamino-propyl)-phosphonic acid | 3-(te...)
Affinity DataIC50:  3.60nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148403((3-Tetradecylamino-propyl)-phosphonic acid | 3-(te...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM101190(US8524917, 163)
Affinity DataIC50:  4nMAssay Description:Inhibition assay using sphingosine-1-phosphate receptor 3.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM101050(US8524917, 23)
Affinity DataIC50:  4nMAssay Description:Inhibition assay using sphingosine-1-phosphate receptor 3.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148391(CHEMBL325193 | {3-[2-(4-Octyl-phenyl)-ethylamino]-...)
Affinity DataIC50:  4.30nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50152328(CHEMBL181597 | [(1S,3S)-3-(4-Nonyl-benzylamino)-cy...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148421(CHEMBL119413 | [3-(3-Chloro-4-octyloxy-benzylamino...)
Affinity DataIC50:  4.90nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM101038(US8524917, 11 | US8563594, 169)
Affinity DataIC50:  5nMAssay Description:Inhibition assay using sphingosine-1-phosphate receptor 3.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM101219(US8524917, 192)
Affinity DataIC50:  5nMAssay Description:Inhibition assay using sphingosine-1-phosphate receptor 3.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM101121(US8524917, 94)
Affinity DataIC50:  5nMAssay Description:Inhibition assay using sphingosine-1-phosphate receptor 3.More data for this Ligand-Target Pair
In DepthDetails US Patent
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