Compile Data Set for Download or QSAR
Found 22 Enz. Inhib. hit(s) with all data for entry = 3073
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27634(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cc(C)ccc2F)c1
Show InChI InChI=1S/C20H18ClFN4O/c1-12-6-7-17(22)16(8-12)20(27)25-15-5-3-4-14(9-15)13(2)24-19-11-23-10-18(21)26-19/h3-11,13H,1-2H3,(H,24,26)(H,25,27)/t13-/m0/s1
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27633(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C20H19ClN4O/c1-13-5-3-7-16(9-13)20(26)24-17-8-4-6-15(10-17)14(2)23-19-12-22-11-18(21)25-19/h3-12,14H,1-2H3,(H,23,25)(H,24,26)/t14-/m0/s1
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27628(5-bromo-N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cncc(Br)c2)c1
Show InChI InChI=1S/C18H15BrClN5O/c1-11(23-17-10-22-9-16(20)25-17)12-3-2-4-15(6-12)24-18(26)13-5-14(19)8-21-7-13/h2-11H,1H3,(H,23,25)(H,24,26)/t11-/m0/s1
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27627(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cncc(C)c2)c1
Show InChI InChI=1S/C19H18ClN5O/c1-12-6-15(9-21-8-12)19(26)24-16-5-3-4-14(7-16)13(2)23-18-11-22-10-17(20)25-18/h3-11,13H,1-2H3,(H,23,25)(H,24,26)/t13-/m0/s1
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27637(N-{3-[(1S)-1-[(5-bromopyridin-3-yl)amino]ethyl]phe...)
Show SMILES C[C@H](Nc1cncc(Br)c1)c1cccc(NC(=O)c2cncc(C)c2)c1
Show InChI InChI=1S/C20H19BrN4O/c1-13-6-16(10-22-9-13)20(26)25-18-5-3-4-15(7-18)14(2)24-19-8-17(21)11-23-12-19/h3-12,14,24H,1-2H3,(H,25,26)/t14-/m0/s1
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27631(3-chloro-N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C19H15Cl2FN4O/c1-11(24-18-10-23-9-17(21)26-18)12-3-2-4-14(7-12)25-19(27)13-5-6-16(22)15(20)8-13/h2-11H,1H3,(H,24,26)(H,25,27)/t11-/m0/s1
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27632(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2ccc(C)cc2)c1
Show InChI InChI=1S/C20H19ClN4O/c1-13-6-8-15(9-7-13)20(26)24-17-5-3-4-16(10-17)14(2)23-19-12-22-11-18(21)25-19/h3-12,14H,1-2H3,(H,23,25)(H,24,26)/t14-/m0/s1
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27630(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C20H16ClF3N4O/c1-12(26-18-11-25-10-17(21)28-18)13-4-3-7-16(9-13)27-19(29)14-5-2-6-15(8-14)20(22,23)24/h2-12H,1H3,(H,26,28)(H,27,29)/t12-/m0/s1
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27639(N-{3-[(1S)-1-{[6-(4-hydroxy-3-methoxyphenyl)pyrazi...)
Show SMILES COc1cc(ccc1O)-c1cncc(N[C@@H](C)c2cccc(NC(=O)c3cccnc3)c2)n1
Show InChI InChI=1S/C25H23N5O3/c1-16(17-5-3-7-20(11-17)29-25(32)19-6-4-10-26-13-19)28-24-15-27-14-21(30-24)18-8-9-22(31)23(12-18)33-2/h3-16,31H,1-2H3,(H,28,30)(H,29,32)/t16-/m0/s1
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27626(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2ccnc(C)c2)c1
Show InChI InChI=1S/C19H18ClN5O/c1-12-8-15(6-7-22-12)19(26)24-16-5-3-4-14(9-16)13(2)23-18-11-21-10-17(20)25-18/h3-11,13H,1-2H3,(H,23,25)(H,24,26)/t13-/m0/s1
Affinity DataIC50: 15nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27619(N-[3-(1-{[6-(4-hydroxy-3-methoxyphenyl)pyrazin-2-y...)
Show SMILES COc1cc(ccc1O)-c1cncc(NC(C)c2cccc(NC(=O)c3cccnc3)c2)n1
Show InChI InChI=1S/C25H23N5O3/c1-16(17-5-3-7-20(11-17)29-25(32)19-6-4-10-26-13-19)28-24-15-27-14-21(30-24)18-8-9-22(31)23(12-18)33-2/h3-16,31H,1-2H3,(H,28,30)(H,29,32)
Affinity DataIC50: 22nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27625(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2ccc(C)nc2)c1
Show InChI InChI=1S/C19H18ClN5O/c1-12-6-7-15(9-22-12)19(26)24-16-5-3-4-14(8-16)13(2)23-18-11-21-10-17(20)25-18/h3-11,13H,1-2H3,(H,23,25)(H,24,26)/t13-/m0/s1
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27629(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C19H17ClN4O/c1-13(22-18-12-21-11-17(20)24-18)15-8-5-9-16(10-15)23-19(25)14-6-3-2-4-7-14/h2-13H,1H3,(H,22,24)(H,23,25)/t13-/m0/s1
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27640(N-{3-[(1R)-1-{[6-(4-hydroxy-3-methoxyphenyl)pyrazi...)
Show SMILES COc1cc(ccc1O)-c1cncc(N[C@H](C)c2cccc(NC(=O)c3cccnc3)c2)n1
Show InChI InChI=1S/C25H23N5O3/c1-16(17-5-3-7-20(11-17)29-25(32)19-6-4-10-26-13-19)28-24-15-27-14-21(30-24)18-8-9-22(31)23(12-18)33-2/h3-16,31H,1-2H3,(H,28,30)(H,29,32)/t16-/m1/s1
Affinity DataIC50: 416nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27620(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cccnc2)c1
Show InChI InChI=1S/C18H16ClN5O/c1-12(22-17-11-21-10-16(19)24-17)13-4-2-6-15(8-13)23-18(25)14-5-3-7-20-9-14/h2-12H,1H3,(H,22,24)(H,23,25)/t12-/m0/s1
Affinity DataIC50: 857nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27635(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cncs2)c1
Show InChI InChI=1S/C16H14ClN5OS/c1-10(20-15-8-18-7-14(17)22-15)11-3-2-4-12(5-11)21-16(23)13-6-19-9-24-13/h2-10H,1H3,(H,20,22)(H,21,23)/t10-/m0/s1
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27621(N-[(1S)-1-(3-aminophenyl)ethyl]-6-chloropyrazin-2-...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(N)c1
Show InChI InChI=1S/C12H13ClN4/c1-8(9-3-2-4-10(14)5-9)16-12-7-15-6-11(13)17-12/h2-8H,14H2,1H3,(H,16,17)/t8-/m0/s1
Affinity DataIC50: 5.00E+3nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27638(N-{3-[(1S)-1-[(6-bromopyridin-2-yl)amino]ethyl]phe...)
Show SMILES C[C@H](Nc1cccc(Br)n1)c1cccc(NC(=O)c2cncc(C)c2)c1
Show InChI InChI=1S/C20H19BrN4O/c1-13-9-16(12-22-11-13)20(26)24-17-6-3-5-15(10-17)14(2)23-19-8-4-7-18(21)25-19/h3-12,14H,1-2H3,(H,23,25)(H,24,26)/t14-/m0/s1
Affinity DataIC50: 5.00E+3nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27622(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(c1)N(C)C(=O)c1cccnc1
Show InChI InChI=1S/C19H18ClN5O/c1-13(23-18-12-22-11-17(20)24-18)14-5-3-7-16(9-14)25(2)19(26)15-6-4-8-21-10-15/h3-13H,1-2H3,(H,23,24)/t13-/m0/s1
Affinity DataIC50: 5.00E+3nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27623(6-chloro-N-[(1S)-1-{3-[(pyridin-3-ylmethyl)amino]p...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NCc2cccnc2)c1
Show InChI InChI=1S/C18H18ClN5/c1-13(23-18-12-21-11-17(19)24-18)15-5-2-6-16(8-15)22-10-14-4-3-7-20-9-14/h2-9,11-13,22H,10H2,1H3,(H,23,24)/t13-/m0/s1
Affinity DataIC50: 5.00E+3nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27624(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NS(=O)(=O)c2cccnc2)c1
Show InChI InChI=1S/C17H16ClN5O2S/c1-12(21-17-11-20-10-16(18)22-17)13-4-2-5-14(8-13)23-26(24,25)15-6-3-7-19-9-15/h2-12,23H,1H3,(H,21,22)/t12-/m0/s1
Affinity DataIC50: 5.00E+3nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cytopia Research Pty Ltd

LigandPNGBDBM27636(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)C2CCCN(C)C2)c1
Show InChI InChI=1S/C19H24ClN5O/c1-13(22-18-11-21-10-17(20)24-18)14-5-3-7-16(9-14)23-19(26)15-6-4-8-25(2)12-15/h3,5,7,9-11,13,15H,4,6,8,12H2,1-2H3,(H,22,24)(H,23,26)/t13-,15?/m0/s1
Affinity DataIC50: 5.00E+3nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...More data for this Ligand-Target Pair