Compile Data Set for Download or QSAR
Found 18 Enz. Inhib. hit(s) with all data for entry = 50006413
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50240041(1-phenyl-2-thiourea | 1-phenylthiourea | CHEMBL263...)
Show SMILES NC(=S)Nc1ccccc1
Show InChI InChI=1S/C7H8N2S/c8-7(10)9-6-4-2-1-3-5-6/h1-5H,(H3,8,9,10)
Affinity DataKi:  300nMAssay Description:Competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate by Lineweaver-Burk plots analysisMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50499815(CHEMBL3739883)
Show SMILES NC(=S)c1ccccc1
Show InChI InChI=1S/C7H7NS/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9)
Affinity DataKi:  700nMAssay Description:Non-competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate by Lineweaver-Burk plots analysisMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50499816(CHEMBL3740596)
Show SMILES CC(=S)Nc1ccccc1
Show InChI InChI=1S/C8H9NS/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)
Affinity DataKi:  1.20E+3nMAssay Description:Competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate by Lineweaver-Burk plots analysisMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50239976(1314 TH | CHEBI:4885 | Ethionamide | Trecator | Tr...)
Show SMILES CCc1cc(ccn1)C(N)=S
Show InChI InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)
Affinity DataKi:  1.90E+3nMAssay Description:Non-competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate by Lineweaver-Burk plots analysisMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50499814(Ektebin | Peteha | Prothionamide | Protionamide | ...)
Show SMILES CCCc1cc(ccn1)C(N)=S
Show InChI InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
Affinity DataKi:  2.40E+3nMAssay Description:Non-competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate by Lineweaver-Burk plots analysisMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50499813(CHEMBL3741839)
Show SMILES NC(=S)c1ccccn1
Show InChI InChI=1S/C6H6N2S/c7-6(9)5-3-1-2-4-8-5/h1-4H,(H2,7,9)
Affinity DataKi:  2.70E+3nMAssay Description:Non-competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate by Lineweaver-Burk plots analysisMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM60920(thionicotinamide)
Show SMILES NC(=S)c1cccnc1
Show InChI InChI=1S/C6H6N2S/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
Affinity DataKi:  4.30E+3nMAssay Description:Non-competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate by Lineweaver-Burk plots analysisMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50499817(CHEMBL2441351)
Show SMILES NC(=S)c1ccncc1
Show InChI InChI=1S/C6H6N2S/c7-6(9)5-1-3-8-4-2-5/h1-4H,(H2,7,9)
Affinity DataKi:  2.23E+4nMAssay Description:Non-competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate by Lineweaver-Burk plots analysisMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50240041(1-phenyl-2-thiourea | 1-phenylthiourea | CHEMBL263...)
Show SMILES NC(=S)Nc1ccccc1
Show InChI InChI=1S/C7H8N2S/c8-7(10)9-6-4-2-1-3-5-6/h1-5H,(H3,8,9,10)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrateMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50499815(CHEMBL3739883)
Show SMILES NC(=S)c1ccccc1
Show InChI InChI=1S/C7H7NS/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrateMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50239976(1314 TH | CHEBI:4885 | Ethionamide | Trecator | Tr...)
Show SMILES CCc1cc(ccn1)C(N)=S
Show InChI InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrateMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50499816(CHEMBL3740596)
Show SMILES CC(=S)Nc1ccccc1
Show InChI InChI=1S/C8H9NS/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrateMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50499814(Ektebin | Peteha | Prothionamide | Protionamide | ...)
Show SMILES CCCc1cc(ccn1)C(N)=S
Show InChI InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrateMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM60920(thionicotinamide)
Show SMILES NC(=S)c1cccnc1
Show InChI InChI=1S/C6H6N2S/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrateMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50499813(CHEMBL3741839)
Show SMILES NC(=S)c1ccccn1
Show InChI InChI=1S/C6H6N2S/c7-6(9)5-3-1-2-4-8-5/h1-4H,(H2,7,9)
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrateMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50499817(CHEMBL2441351)
Show SMILES NC(=S)c1ccncc1
Show InChI InChI=1S/C6H6N2S/c7-6(9)5-1-3-8-4-2-5/h1-4H,(H2,7,9)
Affinity DataIC50: 4.38E+4nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrateMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50240030(Acetanilide | Antifebrin | CHEBI:28884)
Show SMILES CC(=O)Nc1ccccc1
Show InChI InChI=1S/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrateMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50336507(4-pyridinecarbohydrazide(Isoniazid) | CHEMBL64 | D...)
Show SMILES NNC(=O)c1ccncc1
Show InChI InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrateMore data for this Ligand-Target Pair