Compile Data Set for Download or QSAR
Found 39 Enz. Inhib. hit(s) with all data for entry = 50025504
TargetNeutrophil collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15+/m1/s1
Affinity DataIC50: 0.0460nMAssay Description:Inhibition of human recombinant MMP8More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15+/m1/s1
Affinity DataIC50: 0.380nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15+/m1/s1
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant MMP2More data for this Ligand-Target Pair
TargetMatrilysin(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15+/m1/s1
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human recombinant MMP7More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15+/m1/s1
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant MMP1More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15+/m1/s1
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant MMP3More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245248((S)-N4-hydroxy-2-isobutyl-N1-((S)-1-(methylamino)-...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15-/m0/s1
Affinity DataIC50: 48nMAssay Description:Inhibition of human recombinant MMP8More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245248((S)-N4-hydroxy-2-isobutyl-N1-((S)-1-(methylamino)-...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15-/m0/s1
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245248((S)-N4-hydroxy-2-isobutyl-N1-((S)-1-(methylamino)-...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15-/m0/s1
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant MMP2More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245248((S)-N4-hydroxy-2-isobutyl-N1-((S)-1-(methylamino)-...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15-/m0/s1
Affinity DataIC50: 640nMAssay Description:Inhibition of human recombinant MMP1More data for this Ligand-Target Pair
TargetMatrilysin(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245248((S)-N4-hydroxy-2-isobutyl-N1-((S)-1-(methylamino)-...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15-/m0/s1
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of human recombinant MMP7More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245248((S)-N4-hydroxy-2-isobutyl-N1-((S)-1-(methylamino)-...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15-/m0/s1
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant MMP3More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50272134(CHEMBL501715 | N-[(Hydroxyamino)carbonyl]-L-leucyl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)NO
Show InChI InChI=1S/C17H26N4O4/c1-11(2)9-13(20-17(24)21-25)16(23)19-14(15(22)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14,25H,9-10H2,1-3H3,(H,18,22)(H,19,23)(H2,20,21,24)/t13-,14-/m0/s1
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50272134(CHEMBL501715 | N-[(Hydroxyamino)carbonyl]-L-leucyl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)NO
Show InChI InChI=1S/C17H26N4O4/c1-11(2)9-13(20-17(24)21-25)16(23)19-14(15(22)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14,25H,9-10H2,1-3H3,(H,18,22)(H,19,23)(H2,20,21,24)/t13-,14-/m0/s1
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human recombinant MMP2More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50272134(CHEMBL501715 | N-[(Hydroxyamino)carbonyl]-L-leucyl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)NO
Show InChI InChI=1S/C17H26N4O4/c1-11(2)9-13(20-17(24)21-25)16(23)19-14(15(22)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14,25H,9-10H2,1-3H3,(H,18,22)(H,19,23)(H2,20,21,24)/t13-,14-/m0/s1
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of human recombinant MMP8More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245247(CHEMBL452082 | N-[(Hydroxyamino)carbonyl]-D-leucyl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)NO
Show InChI InChI=1S/C17H26N4O4/c1-11(2)9-13(20-17(24)21-25)16(23)19-14(15(22)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14,25H,9-10H2,1-3H3,(H,18,22)(H,19,23)(H2,20,21,24)/t13-,14+/m1/s1
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of human recombinant MMP8More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245247(CHEMBL452082 | N-[(Hydroxyamino)carbonyl]-D-leucyl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)NO
Show InChI InChI=1S/C17H26N4O4/c1-11(2)9-13(20-17(24)21-25)16(23)19-14(15(22)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14,25H,9-10H2,1-3H3,(H,18,22)(H,19,23)(H2,20,21,24)/t13-,14+/m1/s1
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50272134(CHEMBL501715 | N-[(Hydroxyamino)carbonyl]-L-leucyl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)NO
Show InChI InChI=1S/C17H26N4O4/c1-11(2)9-13(20-17(24)21-25)16(23)19-14(15(22)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14,25H,9-10H2,1-3H3,(H,18,22)(H,19,23)(H2,20,21,24)/t13-,14-/m0/s1
Affinity DataIC50: 2.70E+5nMAssay Description:Inhibition of human recombinant MMP1More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245249(CHEMBL452584 | N-(Benzyloxycarbonyl)-L-leucyl-L-ph...)
Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C24H30N2O5/c1-17(2)14-20(26-24(29)31-16-19-12-8-5-9-13-19)22(27)25-21(23(28)30-3)15-18-10-6-4-7-11-18/h4-13,17,20-21H,14-16H2,1-3H3,(H,25,27)(H,26,29)/t20-,21-/m0/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP2More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245249(CHEMBL452584 | N-(Benzyloxycarbonyl)-L-leucyl-L-ph...)
Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C24H30N2O5/c1-17(2)14-20(26-24(29)31-16-19-12-8-5-9-13-19)22(27)25-21(23(28)30-3)15-18-10-6-4-7-11-18/h4-13,17,20-21H,14-16H2,1-3H3,(H,25,27)(H,26,29)/t20-,21-/m0/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP3More data for this Ligand-Target Pair
TargetMatrilysin(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245249(CHEMBL452584 | N-(Benzyloxycarbonyl)-L-leucyl-L-ph...)
Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C24H30N2O5/c1-17(2)14-20(26-24(29)31-16-19-12-8-5-9-13-19)22(27)25-21(23(28)30-3)15-18-10-6-4-7-11-18/h4-13,17,20-21H,14-16H2,1-3H3,(H,25,27)(H,26,29)/t20-,21-/m0/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP7More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245249(CHEMBL452584 | N-(Benzyloxycarbonyl)-L-leucyl-L-ph...)
Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C24H30N2O5/c1-17(2)14-20(26-24(29)31-16-19-12-8-5-9-13-19)22(27)25-21(23(28)30-3)15-18-10-6-4-7-11-18/h4-13,17,20-21H,14-16H2,1-3H3,(H,25,27)(H,26,29)/t20-,21-/m0/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP8More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245250(CHEMBL445994 | L-Leucyl-L-phenylalanine methylamid...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C
Show InChI InChI=1S/C16H25N3O2/c1-11(2)9-13(17)15(20)19-14(16(21)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14H,9-10,17H2,1-3H3,(H,18,21)(H,19,20)/t13-,14-/m0/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP2More data for this Ligand-Target Pair
TargetMatrilysin(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245250(CHEMBL445994 | L-Leucyl-L-phenylalanine methylamid...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C
Show InChI InChI=1S/C16H25N3O2/c1-11(2)9-13(17)15(20)19-14(16(21)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14H,9-10,17H2,1-3H3,(H,18,21)(H,19,20)/t13-,14-/m0/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP7More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245251(CHEMBL510082 | D-Leucyl-L-phenylalanine methylamid...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)CC(C)C
Show InChI InChI=1S/C16H25N3O2/c1-11(2)9-13(17)15(20)19-14(16(21)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14H,9-10,17H2,1-3H3,(H,18,21)(H,19,20)/t13-,14+/m1/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP1More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245251(CHEMBL510082 | D-Leucyl-L-phenylalanine methylamid...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)CC(C)C
Show InChI InChI=1S/C16H25N3O2/c1-11(2)9-13(17)15(20)19-14(16(21)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14H,9-10,17H2,1-3H3,(H,18,21)(H,19,20)/t13-,14+/m1/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP2More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245251(CHEMBL510082 | D-Leucyl-L-phenylalanine methylamid...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)CC(C)C
Show InChI InChI=1S/C16H25N3O2/c1-11(2)9-13(17)15(20)19-14(16(21)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14H,9-10,17H2,1-3H3,(H,18,21)(H,19,20)/t13-,14+/m1/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP3More data for this Ligand-Target Pair
TargetMatrilysin(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245251(CHEMBL510082 | D-Leucyl-L-phenylalanine methylamid...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)CC(C)C
Show InChI InChI=1S/C16H25N3O2/c1-11(2)9-13(17)15(20)19-14(16(21)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14H,9-10,17H2,1-3H3,(H,18,21)(H,19,20)/t13-,14+/m1/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP7More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245249(CHEMBL452584 | N-(Benzyloxycarbonyl)-L-leucyl-L-ph...)
Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C24H30N2O5/c1-17(2)14-20(26-24(29)31-16-19-12-8-5-9-13-19)22(27)25-21(23(28)30-3)15-18-10-6-4-7-11-18/h4-13,17,20-21H,14-16H2,1-3H3,(H,25,27)(H,26,29)/t20-,21-/m0/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP1More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245251(CHEMBL510082 | D-Leucyl-L-phenylalanine methylamid...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)CC(C)C
Show InChI InChI=1S/C16H25N3O2/c1-11(2)9-13(17)15(20)19-14(16(21)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14H,9-10,17H2,1-3H3,(H,18,21)(H,19,20)/t13-,14+/m1/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP8More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245251(CHEMBL510082 | D-Leucyl-L-phenylalanine methylamid...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)CC(C)C
Show InChI InChI=1S/C16H25N3O2/c1-11(2)9-13(17)15(20)19-14(16(21)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14H,9-10,17H2,1-3H3,(H,18,21)(H,19,20)/t13-,14+/m1/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245249(CHEMBL452584 | N-(Benzyloxycarbonyl)-L-leucyl-L-ph...)
Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C24H30N2O5/c1-17(2)14-20(26-24(29)31-16-19-12-8-5-9-13-19)22(27)25-21(23(28)30-3)15-18-10-6-4-7-11-18/h4-13,17,20-21H,14-16H2,1-3H3,(H,25,27)(H,26,29)/t20-,21-/m0/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245250(CHEMBL445994 | L-Leucyl-L-phenylalanine methylamid...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C
Show InChI InChI=1S/C16H25N3O2/c1-11(2)9-13(17)15(20)19-14(16(21)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14H,9-10,17H2,1-3H3,(H,18,21)(H,19,20)/t13-,14-/m0/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair
TargetMatrilysin(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245247(CHEMBL452082 | N-[(Hydroxyamino)carbonyl]-D-leucyl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)NO
Show InChI InChI=1S/C17H26N4O4/c1-11(2)9-13(20-17(24)21-25)16(23)19-14(15(22)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14,25H,9-10H2,1-3H3,(H,18,22)(H,19,23)(H2,20,21,24)/t13-,14+/m1/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP7More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245247(CHEMBL452082 | N-[(Hydroxyamino)carbonyl]-D-leucyl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)NO
Show InChI InChI=1S/C17H26N4O4/c1-11(2)9-13(20-17(24)21-25)16(23)19-14(15(22)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14,25H,9-10H2,1-3H3,(H,18,22)(H,19,23)(H2,20,21,24)/t13-,14+/m1/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP3More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245247(CHEMBL452082 | N-[(Hydroxyamino)carbonyl]-D-leucyl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)NO
Show InChI InChI=1S/C17H26N4O4/c1-11(2)9-13(20-17(24)21-25)16(23)19-14(15(22)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14,25H,9-10H2,1-3H3,(H,18,22)(H,19,23)(H2,20,21,24)/t13-,14+/m1/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP2More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50245247(CHEMBL452082 | N-[(Hydroxyamino)carbonyl]-D-leucyl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)NO
Show InChI InChI=1S/C17H26N4O4/c1-11(2)9-13(20-17(24)21-25)16(23)19-14(15(22)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14,25H,9-10H2,1-3H3,(H,18,22)(H,19,23)(H2,20,21,24)/t13-,14+/m1/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP1More data for this Ligand-Target Pair
TargetMatrilysin(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50272134(CHEMBL501715 | N-[(Hydroxyamino)carbonyl]-L-leucyl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)NO
Show InChI InChI=1S/C17H26N4O4/c1-11(2)9-13(20-17(24)21-25)16(23)19-14(15(22)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14,25H,9-10H2,1-3H3,(H,18,22)(H,19,23)(H2,20,21,24)/t13-,14-/m0/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP7More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Università G. d'Annunzio

Curated by ChEMBL
LigandPNGBDBM50272134(CHEMBL501715 | N-[(Hydroxyamino)carbonyl]-L-leucyl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)NO
Show InChI InChI=1S/C17H26N4O4/c1-11(2)9-13(20-17(24)21-25)16(23)19-14(15(22)18-3)10-12-7-5-4-6-8-12/h4-8,11,13-14,25H,9-10H2,1-3H3,(H,18,22)(H,19,23)(H2,20,21,24)/t13-,14-/m0/s1
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant MMP3More data for this Ligand-Target Pair