Found 24 Enz. Inhib. hit(s) with all data for entry = 50047818 TargetDNA polymerase iota(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of human recombinant DNA polymerase iota expressed in Baculovirus expression system using TAMRA/BHQ-2-labeled primer/template measured at ...More data for this Ligand-Target Pair
TargetDNA polymerase eta(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of human recombinant DNA polymerase eta expressed in Baculovirus expression system using TAMRA/BHQ-2-labeled primer/template measured at 2...More data for this Ligand-Target Pair
TargetDNA polymerase eta(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant DNA polymerase eta expressed in Baculovirus expression system using TAMRA/BHQ-2-labeled primer/template measured at 2...More data for this Ligand-Target Pair
TargetDNA polymerase iota(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant DNA polymerase iota expressed in Baculovirus expression system using TAMRA/BHQ-2-labeled primer/template measured at ...More data for this Ligand-Target Pair
TargetWD repeat-containing protein 48(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 540nMAssay Description:Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate preincubated for 30 mins followed by substrate addition by fluorescence-based HTS ass...More data for this Ligand-Target Pair
TargetWD repeat-containing protein 48(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 880nMAssay Description:Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate preincubated for 30 mins followed by substrate addition by fluorescence-based HTS ass...More data for this Ligand-Target Pair
TargetProliferating cell nuclear antigen(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to full length human PCNA expressed in Escherichia coli BL21(DE3) assessed as inhibition of interaction with N-terminal 5-carboxyflu...More data for this Ligand-Target Pair
3D Structure (crystal)TargetWD repeat-containing protein 48(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assayMore data for this Ligand-Target Pair
TargetDNA polymerase kappa(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human DNA polymerase kappa (19 to 526 residues) preincubated for 15 mins followed by replicating non-damaged DNA substrate addition mea...More data for this Ligand-Target Pair
TargetWD repeat-containing protein 48(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assayMore data for this Ligand-Target Pair
TargetDNA polymerase kappa(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human DNA polymerase kappa (19 to 526 residues)-mediated TLS past acrolein derived ring-opened reduced form of gamma-HOPdG lesions prei...More data for this Ligand-Target Pair
TargetDNA polymerase kappa(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human DNA polymerase kappa (19 to 526 residues)-mediated TLS past acrolein derived ring-opened reduced form of gamma-HOPdG lesions prei...More data for this Ligand-Target Pair
TargetDNA polymerase kappa(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human DNA polymerase kappa (19 to 526 residues)-mediated TLS past acrolein derived ring-opened reduced form of gamma-HOPdG lesions prei...More data for this Ligand-Target Pair
TargetDNA polymerase iota(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human DNA polymerase iota preincubated for 15 mins followed by replicating non-damaged DNA substrate addition measured after 30 mins in...More data for this Ligand-Target Pair
TargetWD repeat-containing protein 48(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assayMore data for this Ligand-Target Pair
TargetWD repeat-containing protein 48(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assayMore data for this Ligand-Target Pair
TargetWD repeat-containing protein 48(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assayMore data for this Ligand-Target Pair
TargetDNA polymerase kappa(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of human DNA polymerase kappa (19 to 526 residues) preincubated for 15 mins followed by replicating non-damaged DNA substrate addition mea...More data for this Ligand-Target Pair
TargetDNA polymerase eta(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of human DNA polymerase eta (1 to 437 residues) preincubated for 15 mins followed by replicating non-damaged DNA substrate addition measur...More data for this Ligand-Target Pair
TargetDNA polymerase kappa(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of C-terminal His6-tagged human DNA polymerase kappa (1 to 560 residues) expressed in Escherichia coli using poly(dA)/oligo(dT)18 and [3H]...More data for this Ligand-Target Pair
TargetDNA polymerase kappa(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human DNA polymerase kappa (19 to 526 residues) preincubated for 15 mins followed by replicating non-damaged DNA substrate addition mea...More data for this Ligand-Target Pair
TargetProliferating cell nuclear antigen(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Binding affinity to monoubiquitinated PCNA derived from human GM04312 cells assessed as inhibition of interaction with His8-tagged DNA polymerase eta...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of C-terminal His6-tagged recombinant mouse DNA polymerase iota using poly(dA)/oligo(dT)18 and [3H]dTTP as template-primer and nucleotide ...More data for this Ligand-Target Pair
TargetDNA polymerase eta(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by ChEMBL
University Of Connecticut Health Center
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of C-terminal His6-tagged human DNA polymerase eta (1 to 511 residues) expressed in Escherichia coli using poly(dA)/oligo(dT)18 and [3H]dT...More data for this Ligand-Target Pair
